Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Fluid shear stress and atherosclerosis 💬
1件: ACVR2A 💬 D09670 💬 Sotatercept 2件: 86, 284 💬
2 Fluid shear stress and atherosclerosis 💬
2件: ACVR2A, ACVR2B 💬 D10620 💬 Bimagrumab 1件: 15 💬
3 Fluid shear stress and atherosclerosis 💬
1件: BCL2 💬 D10679 💬 Venetoclax 1件: 28 💬
4 Fluid shear stress and atherosclerosis 💬
1件: BMPR2 💬 D03779 💬 Dibotermin alfa 1件: 34 💬
5 Fluid shear stress and atherosclerosis 💬
4件: CCL2, IL1A, IL1B, TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
6 Fluid shear stress and atherosclerosis 💬
1件: HMOX1 💬 D05922 💬 Stannsoporfin 1件: 254 💬
7 Fluid shear stress and atherosclerosis 💬
1件: IFNG 💬 D11120 💬 Emapalumab 2件: 49, 107 💬
8 Fluid shear stress and atherosclerosis 💬
1件: IFNG 💬 D04242 💬 Fontolizumab 1件: 46 💬
9 Fluid shear stress and atherosclerosis 💬
1件: IL1A 💬 D11253 💬 Bermekimab 1件: 51 💬
10 Fluid shear stress and atherosclerosis 💬
2件: IL1A, IL1B 💬 D06635 💬 Rilonacept 4件: 51, 106, 107, 266 💬
11 Fluid shear stress and atherosclerosis 💬
1件: IL1B 💬 D09315 💬 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
12 Fluid shear stress and atherosclerosis 💬
1件: IL1B 💬 D09911 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
13 Fluid shear stress and atherosclerosis 💬
2件: IL1R1, IL1R2 💬 D02934 💬 Anakinra 19件:  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
14 Fluid shear stress and atherosclerosis 💬
1件: KDR 💬 D03218 💬 Axitinib 1件: 34 💬
15 Fluid shear stress and atherosclerosis 💬
1件: KDR 💬 D10062 💬 Cabozantinib 1件: 34 💬
16 Fluid shear stress and atherosclerosis 💬
1件: KDR 💬 D08881 💬 Cediranib 1件: 34 💬
17 Fluid shear stress and atherosclerosis 💬
1件: KDR 💬 D10481 💬 Nintedanib 5件: 51, 85, 89, 227, 228 💬
18 Fluid shear stress and atherosclerosis 💬
1件: KDR 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
19 Fluid shear stress and atherosclerosis 💬
1件: KDR 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
20 Fluid shear stress and atherosclerosis 💬
1件: KDR 💬 D06402 💬 Sunitinib 2件: 28, 34 💬
21 Fluid shear stress and atherosclerosis 💬
1件: KDR 💬 D08552 💬 Sunitinib 2件: 28, 34 💬
22 Fluid shear stress and atherosclerosis 💬
1件: KDR 💬 D11772 💬 Tesevatinib 1件: 67 💬
23 Fluid shear stress and atherosclerosis 💬
1件: KEAP1 💬 D03846 💬 Dimethyl fumarate 5件: 13, 49, 51, 86, 296 💬
24 Fluid shear stress and atherosclerosis 💬
1件: MAP3K5 💬 D10988 💬 Selonsertib 1件: 86 💬
25 Fluid shear stress and atherosclerosis 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
26 Fluid shear stress and atherosclerosis 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
27 Fluid shear stress and atherosclerosis 💬
1件: NFE2L2 💬 D10964 💬 Omaveloxolone 1件: 18 💬
28 Fluid shear stress and atherosclerosis 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
29 Fluid shear stress and atherosclerosis 💬
1件: NQO1 💬 D00564 💬 Warfarin 13件:  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
30 Fluid shear stress and atherosclerosis 💬
1件: NQO1 💬 D01280 💬 Warfarin 13件:  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
31 Fluid shear stress and atherosclerosis 💬
1件: NQO1 💬 D08682 💬 Warfarin 13件:  6 ,  8 , 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97 💬
32 Fluid shear stress and atherosclerosis 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
33 Fluid shear stress and atherosclerosis 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
34 Fluid shear stress and atherosclerosis 💬
2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
35 Fluid shear stress and atherosclerosis 💬
2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
36 Fluid shear stress and atherosclerosis 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
37 Fluid shear stress and atherosclerosis 💬
1件: SRC 💬 D03252 💬 Bosutinib 2件:  2 , 67 💬
38 Fluid shear stress and atherosclerosis 💬
1件: SRC 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
39 Fluid shear stress and atherosclerosis 💬
1件: SRC 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
40 Fluid shear stress and atherosclerosis 💬
1件: SRC 💬 D09664 💬 Saracatinib 3件:  6 , 89, 272 💬
41 Fluid shear stress and atherosclerosis 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
42 Fluid shear stress and atherosclerosis 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
43 Fluid shear stress and atherosclerosis 💬
1件: TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
44 Fluid shear stress and atherosclerosis 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
45 Fluid shear stress and atherosclerosis 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
46 Fluid shear stress and atherosclerosis 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
47 Fluid shear stress and atherosclerosis 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
48 Fluid shear stress and atherosclerosis 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
49 Fluid shear stress and atherosclerosis 💬
1件: TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
50 Fluid shear stress and atherosclerosis 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
51 Fluid shear stress and atherosclerosis 💬
1件: VEGFA 💬 D09574 💬 Aflibercept 2件: 90, 166 💬
52 Fluid shear stress and atherosclerosis 💬
1件: VEGFA 💬 D06409 💬 Bevacizumab 9件: 13, 34, 85, 86, 87, 89, 227, 280, 331 💬
53 Fluid shear stress and atherosclerosis 💬
1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬