Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Gap junction 💬
1件: ADRB1 💬 D00636 💬 Amiodarone 2件: 28, 127 💬
2 Gap junction 💬
1件: ADRB1 💬 D02910 💬 Amiodarone 2件: 28, 127 💬
3 Gap junction 💬
1件: ADRB1 💬 D00235 💬 Atenolol 1件: 167 💬
4 Gap junction 💬
1件: ADRB1 💬 D00634 💬 Bisoprolol 3件: 67, 86, 113 💬
5 Gap junction 💬
1件: ADRB1 💬 D02342 💬 Bisoprolol 3件: 67, 86, 113 💬
6 Gap junction 💬
1件: ADRB1 💬 D00255 💬 Carvedilol 5件:  6 , 57, 86, 113, 210 💬
7 Gap junction 💬
1件: ADRB1 💬 D03415 💬 Carvedilol 5件:  6 , 57, 86, 113, 210 💬
8 Gap junction 💬
1件: ADRB1 💬 D07660 💬 Celiprolol 1件: 168 💬
9 Gap junction 💬
1件: ADRB1 💬 D02349 💬 Dipivefrin 1件:  6  💬
10 Gap junction 💬
1件: ADRB1 💬 D00632 💬 Dobutamine 3件: 57, 58, 215 💬
11 Gap junction 💬
1件: ADRB1 💬 D03879 💬 Dobutamine 3件: 57, 58, 215 💬
12 Gap junction 💬
1件: ADRB1 💬 D03880 💬 Dobutamine 3件: 57, 58, 215 💬
13 Gap junction 💬
1件: ADRB1 💬 D03881 💬 Dobutamine 3件: 57, 58, 215 💬
14 Gap junction 💬
1件: ADRB1 💬 D01277 💬 Droxidopa 5件:  5 ,  6 , 17, 169, 170 💬
15 Gap junction 💬
1件: ADRB1 💬 D00124 💬 Ephedrine 1件: 11 💬
16 Gap junction 💬
1件: ADRB1 💬 D00095 💬 Epinephrine 3件: 46, 70, 96 💬
17 Gap junction 💬
1件: ADRB1 💬 D00996 💬 Epinephrine 3件: 46, 70, 96 💬
18 Gap junction 💬
1件: ADRB1 💬 D02149 💬 Epinephrine 3件: 46, 70, 96 💬
19 Gap junction 💬
1件: ADRB1 💬 D00644 💬 Esmolol 1件: 58 💬
20 Gap junction 💬
1件: ADRB1 💬 D07916 💬 Esmolol 1件: 58 💬
21 Gap junction 💬
1件: ADRB1 💬 D00601 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
22 Gap junction 💬
1件: ADRB1 💬 D02358 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
23 Gap junction 💬
1件: ADRB1 💬 D05011 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
24 Gap junction 💬
1件: ADRB1 💬 D00432 💬 Nadolol 1件:  6  💬
25 Gap junction 💬
1件: ADRB1 💬 D05127 💬 Nebivolol 4件: 17, 85, 113, 167 💬
26 Gap junction 💬
1件: ADRB1 💬 D00076 💬 Norepinephrine 1件: 22 💬
27 Gap junction 💬
1件: ADRB1 💬 D05206 💬 Norepinephrine 1件: 22 💬
28 Gap junction 💬
1件: ADRB1 💬 D00483 💬 Propranolol 7件:  6 , 158, 167, 215, 227, 278, 296 💬
29 Gap junction 💬
1件: ADRB1 💬 D08443 💬 Propranolol 7件:  6 , 158, 167, 215, 227, 278, 296 💬
30 Gap junction 💬
1件: ADRB1 💬 D00485 💬 Pseudoephedrine 1件: 17 💬
31 Gap junction 💬
1件: ADRB1 💬 D05648 💬 Pseudoephedrine 1件: 17 💬
32 Gap junction 💬
1件: ADRB1 💬 D05649 💬 Pseudoephedrine 1件: 17 💬
33 Gap junction 💬
1件: ADRB1 💬 D08449 💬 Pseudoephedrine 1件: 17 💬
34 Gap junction 💬
1件: ADRB1 💬 D00378 💬 Timolol 2件: 157, 227 💬
35 Gap junction 💬
1件: ADRB1 💬 D00603 💬 Timolol 2件: 157, 227 💬
36 Gap junction 💬
1件: ADRB1 💬 D08600 💬 Timolol 2件: 157, 227 💬
37 Gap junction 💬
1件: DRD1 💬 D11431 💬 Tavapadon 1件:  6  💬
38 Gap junction 💬
2件: DRD1, DRD2 💬 D02004 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
39 Gap junction 💬
2件: DRD1, DRD2 💬 D07460 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
40 Gap junction 💬
2件: DRD1, DRD2 💬 D09886 💬 Dexpramipexole 1件:  2  💬
41 Gap junction 💬
2件: DRD1, DRD2 💬 D00633 💬 Dopamine 4件:  6 ,  7 , 74, 299 💬
42 Gap junction 💬
2件: DRD1, DRD2 💬 D07870 💬 Dopamine 4件:  6 ,  7 , 74, 299 💬
43 Gap junction 💬
2件: DRD1, DRD2 💬 D01044 💬 Flupentixol 1件: 97 💬
44 Gap junction 💬
2件: DRD1, DRD2 💬 D11839 💬 Foslevodopa 1件:  6  💬
45 Gap junction 💬
2件: DRD1, DRD2 💬 D00059 💬 Levodopa 8件:  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
46 Gap junction 💬
2件: DRD1, DRD2 💬 D00502 💬 Pergolide 1件:  6  💬
47 Gap junction 💬
2件: DRD1, DRD2 💬 D08339 💬 Pergolide 1件:  6  💬
48 Gap junction 💬
1件: DRD2 💬 D00780 💬 Bromocriptine 2件:  6 , 74 💬
49 Gap junction 💬
1件: DRD2 💬 D03165 💬 Bromocriptine 2件:  6 , 74 💬
50 Gap junction 💬
1件: DRD2 💬 D00702 💬 Buspirone 3件:  6 , 51, 179 💬
51 Gap junction 💬
1件: DRD2 💬 D07593 💬 Buspirone 3件:  6 , 51, 179 💬
52 Gap junction 💬
1件: DRD2 💬 D00987 💬 Cabergoline 3件:  6 , 74, 75 💬
53 Gap junction 💬
1件: DRD2 💬 D01745 💬 Domperidone 5件:  6 , 13, 17, 51, 230 💬
54 Gap junction 💬
1件: DRD2 💬 D07868 💬 Domperidone 5件:  6 , 13, 17, 51, 230 💬
55 Gap junction 💬
1件: DRD2 💬 D00136 💬 Haloperidol 1件:  8  💬
56 Gap junction 💬
1件: DRD2 💬 D01898 💬 Haloperidol 1件:  8  💬
57 Gap junction 💬
1件: DRD2 💬 D01462 💬 Lisuride 2件:  6 , 86 💬
58 Gap junction 💬
1件: DRD2 💬 D08132 💬 Lisuride 2件:  6 , 86 💬
59 Gap junction 💬
1件: DRD2 💬 D07309 💬 Melperone 1件:  6  💬
60 Gap junction 💬
1件: DRD2 💬 D00726 💬 Metoclopramide 1件: 51 💬
61 Gap junction 💬
1件: DRD2 💬 D02213 💬 Metoclopramide 1件: 51 💬
62 Gap junction 💬
1件: DRD2 💬 D05008 💬 Metoclopramide 1件: 51 💬
63 Gap junction 💬
1件: DRD2 💬 D09397 💬 Pardoprunox 1件:  6  💬
64 Gap junction 💬
1件: DRD2 💬 D00560 💬 Pimozide 1件:  2  💬
65 Gap junction 💬
1件: DRD2 💬 D07305 💬 Piribedil 1件:  6  💬
66 Gap junction 💬
1件: DRD2 💬 D00559 💬 Pramipexole 3件:  2 ,  6 , 20 💬
67 Gap junction 💬
1件: DRD2 💬 D05575 💬 Pramipexole 3件:  2 ,  6 , 20 💬
68 Gap junction 💬
1件: DRD2 💬 D09953 💬 Pridopidine 3件:  2 ,  6 ,  8  💬
69 Gap junction 💬
1件: DRD2 💬 D00784 💬 Ropinirole 4件:  2 ,  6 , 74, 309 💬
70 Gap junction 💬
1件: DRD2 💬 D08489 💬 Ropinirole 4件:  2 ,  6 , 74, 309 💬
71 Gap junction 💬
1件: DRD2 💬 D05768 💬 Rotigotine 2件:  6 , 127 💬
72 Gap junction 💬
1件: DRD2 💬 D01226 💬 Sulpiride 5件:  2 ,  6 , 17, 46, 70 💬
73 Gap junction 💬
1件: DRD2 💬 D08549 💬 Sulpiride 5件:  2 ,  6 , 17, 46, 70 💬
74 Gap junction 💬
1件: DRD2 💬 D01348 💬 Terguride 2件: 51, 86 💬
75 Gap junction 💬
1件: DRD2 💬 D08590 💬 Tiapride 1件:  8  💬
76 Gap junction 💬
1件: DRD2 💬 D00799 💬 Trifluoperazine 2件: 283, 284 💬
77 Gap junction 💬
1件: DRD2 💬 D01448 💬 Trifluoperazine 2件: 283, 284 💬
78 Gap junction 💬
1件: DRD2 💬 D08636 💬 Trifluoperazine 2件: 283, 284 💬
79 Gap junction 💬
2件: DRD2, HTR2A 💬 D01164 💬 Aripiprazole 2件:  6 , 206 💬
80 Gap junction 💬
2件: DRD2, HTR2A 💬 D09997 💬 Cariprazine 1件: 21 💬
81 Gap junction 💬
2件: DRD2, HTR2A 💬 D00458 💬 Quetiapine 2件:  6 , 13 💬
82 Gap junction 💬
2件: DRD2, HTR2A 💬 D08456 💬 Quetiapine 2件:  6 , 13 💬
83 Gap junction 💬
2件: DRD2, HTR2A 💬 D00426 💬 Risperidone 5件:  8 , 156, 179, 187, 206 💬
84 Gap junction 💬
4件: DRD2, HTR2A, HTR2B, HTR2C 💬 D00270 💬 Chlorpromazine 1件: 254 💬
85 Gap junction 💬
4件: DRD2, HTR2A, HTR2B, HTR2C 💬 D00789 💬 Chlorpromazine 1件: 254 💬
86 Gap junction 💬
4件: DRD2, HTR2A, HTR2B, HTR2C 💬 D03274 💬 Chlorpromazine 1件: 254 💬
87 Gap junction 💬
4件: DRD2, HTR2A, HTR2B, HTR2C 💬 D04034 💬 Chlorpromazine 1件: 254 💬
88 Gap junction 💬
4件: DRD2, HTR2A, HTR2B, HTR2C 💬 D00454 💬 Olanzapine 2件:  2 ,  8  💬
89 Gap junction 💬
4件: DRD2, HTR2A, HTR2B, HTR2C 💬 D06623 💬 Olanzapine 2件:  2 ,  8  💬
90 Gap junction 💬
1件: EGFR 💬 D03455 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
91 Gap junction 💬
1件: EGFR 💬 D04023 💬 Erlotinib 1件: 94 💬
92 Gap junction 💬
1件: EGFR 💬 D07907 💬 Erlotinib 1件: 94 💬
93 Gap junction 💬
1件: EGFR 💬 D01977 💬 Gefitinib 1件: 75 💬
94 Gap junction 💬
1件: EGFR 💬 D11251 💬 Icotinib 1件: 34 💬
95 Gap junction 💬
1件: EGFR 💬 D04024 💬 Lapatinib 3件: 34, 74, 75 💬
96 Gap junction 💬
1件: EGFR 💬 D08108 💬 Lapatinib 3件: 34, 74, 75 💬
97 Gap junction 💬
1件: EGFR 💬 D11772 💬 Tesevatinib 1件: 67 💬
98 Gap junction 💬
3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 D00517 💬 Amyl Nitrite 1件: 58 💬
99 Gap junction 💬
3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 D09572 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬
100 Gap junction 💬
1件: HTR2A 💬 D00274 💬 Cisapride 1件: 13 💬
101 Gap junction 💬
1件: HTR2A 💬 D02092 💬 Cisapride 1件: 13 💬
102 Gap junction 💬
1件: HTR2A 💬 D09645 💬 Nelotanserin 1件:  6  💬
103 Gap junction 💬
3件: HTR2A, HTR2B, HTR2C 💬 D07945 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
104 Gap junction 💬
3件: HTR2A, HTR2B, HTR2C 💬 D00820 💬 Trazodone 1件:  2  💬
105 Gap junction 💬
3件: HTR2A, HTR2B, HTR2C 💬 D08626 💬 Trazodone 1件:  2  💬
106 Gap junction 💬
2件: HTR2A, HTR2C 💬 D00283 💬 Clozapine 1件:  6  💬
107 Gap junction 💬
1件: HTR2C 💬 D02578 💬 Agomelatine 1件:  6  💬
108 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
109 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
110 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
111 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
112 Gap junction 💬
1件: PDGFRA 💬 D01441 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
113 Gap junction 💬
1件: PDGFRA 💬 D08066 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
114 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 D08953 💬 Nilotinib 5件:  6 ,  8 , 34, 51, 86 💬
115 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 D10481 💬 Nintedanib 5件: 51, 85, 89, 227, 228 💬
116 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 D06402 💬 Sunitinib 2件: 28, 34 💬
117 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 D08552 💬 Sunitinib 2件: 28, 34 💬
118 Gap junction 💬
2件: PDGFRB, RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
119 Gap junction 💬
2件: PDGFRB, RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
120 Gap junction 💬
2件: PDGFRB, SRC 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
121 Gap junction 💬
2件: PDGFRB, SRC 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
122 Gap junction 💬
1件: SRC 💬 D03252 💬 Bosutinib 2件:  2 , 67 💬
123 Gap junction 💬
1件: SRC 💬 D09664 💬 Saracatinib 3件:  6 , 89, 272 💬
124 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D11595 💬 Belantamab mafodotin 1件: 28 💬
125 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D09587 💬 Brentuximab vedotin 2件: 49, 51 💬
126 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D00570 💬 Colchicine 7件:  2 , 42, 46, 56, 93, 210, 266 💬
127 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D00491 💬 Paclitaxel 2件: 46, 85 💬
128 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D05333 💬 Paclitaxel 2件: 46, 85 💬
129 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D01068 💬 Vinblastine 2件: 34, 65 💬
130 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D08675 💬 Vinblastine 2件: 34, 65 💬
131 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D02197 💬 Vincristine 4件: 26, 34, 65, 331 💬
132 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 D08679 💬 Vincristine 4件: 26, 34, 65, 331 💬