Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 HIF-1 signaling pathway 💬
1件: BCL2 💬 D10679 💬 Venetoclax 1件: 28 💬
2 HIF-1 signaling pathway 💬
1件: EGFR 💬 D03455 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
3 HIF-1 signaling pathway 💬
1件: EGFR 💬 D04023 💬 Erlotinib 1件: 94 💬
4 HIF-1 signaling pathway 💬
1件: EGFR 💬 D07907 💬 Erlotinib 1件: 94 💬
5 HIF-1 signaling pathway 💬
1件: EGFR 💬 D01977 💬 Gefitinib 1件: 75 💬
6 HIF-1 signaling pathway 💬
1件: EGFR 💬 D11251 💬 Icotinib 1件: 34 💬
7 HIF-1 signaling pathway 💬
2件: EGFR, ERBB2 💬 D04024 💬 Lapatinib 3件: 34, 74, 75 💬
8 HIF-1 signaling pathway 💬
2件: EGFR, ERBB2 💬 D08108 💬 Lapatinib 3件: 34, 74, 75 💬
9 HIF-1 signaling pathway 💬
2件: EGFR, ERBB2 💬 D11772 💬 Tesevatinib 1件: 67 💬
10 HIF-1 signaling pathway 💬
1件: FLT1 💬 D03218 💬 Axitinib 1件: 34 💬
11 HIF-1 signaling pathway 💬
1件: FLT1 💬 D08881 💬 Cediranib 1件: 34 💬
12 HIF-1 signaling pathway 💬
1件: FLT1 💬 D10481 💬 Nintedanib 5件: 51, 85, 89, 227, 228 💬
13 HIF-1 signaling pathway 💬
1件: FLT1 💬 D06402 💬 Sunitinib 2件: 28, 34 💬
14 HIF-1 signaling pathway 💬
1件: FLT1 💬 D08552 💬 Sunitinib 2件: 28, 34 💬
15 HIF-1 signaling pathway 💬
1件: HMOX1 💬 D05922 💬 Stannsoporfin 1件: 254 💬
16 HIF-1 signaling pathway 💬
1件: IFNG 💬 D11120 💬 Emapalumab 2件: 49, 107 💬
17 HIF-1 signaling pathway 💬
1件: IFNG 💬 D04242 💬 Fontolizumab 1件: 46 💬
18 HIF-1 signaling pathway 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
19 HIF-1 signaling pathway 💬
1件: IGF1R 💬 D09925 💬 Linsitinib 1件: 232 💬
20 HIF-1 signaling pathway 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
21 HIF-1 signaling pathway 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
22 HIF-1 signaling pathway 💬
1件: IGF1R 💬 D09680 💬 Teprotumumab 1件: 51 💬
23 HIF-1 signaling pathway 💬
1件: IL6 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
24 HIF-1 signaling pathway 💬
1件: IL6 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
25 HIF-1 signaling pathway 💬
1件: IL6 💬 D09669 💬 Siltuximab 2件: 28, 331 💬
26 HIF-1 signaling pathway 💬
1件: IL6 💬 D10080 💬 Sirukumab 2件: 41, 46 💬
27 HIF-1 signaling pathway 💬
1件: IL6R 💬 D10161 💬 Sarilumab 5件: 41, 46, 84, 107, 271 💬
28 HIF-1 signaling pathway 💬
1件: IL6R 💬 D11079 💬 Satralizumab 2件: 11, 13 💬
29 HIF-1 signaling pathway 💬
1件: IL6R 💬 D02596 💬 Tocilizumab 21件:  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
30 HIF-1 signaling pathway 💬
1件: INSR 💬 D04539 💬 Insulin detemir 1件: 299 💬
31 HIF-1 signaling pathway 💬
1件: INSR 💬 D03250 💬 Insulin glargine 1件: 299 💬
32 HIF-1 signaling pathway 💬
1件: INSR 💬 D00085 💬 Insulin human 2件: 96, 156 💬
33 HIF-1 signaling pathway 💬
1件: INSR 💬 D03230 💬 Insulin human 2件: 96, 156 💬
34 HIF-1 signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
35 HIF-1 signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
36 HIF-1 signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
37 HIF-1 signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
38 HIF-1 signaling pathway 💬
1件: MTOR 💬 D02714 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
39 HIF-1 signaling pathway 💬
1件: MTOR 💬 D00753 💬 Sirolimus 41件:  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
40 HIF-1 signaling pathway 💬
1件: MTOR 💬 D06068 💬 Temsirolimus 4件: 13, 34, 89, 331 💬
41 HIF-1 signaling pathway 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
42 HIF-1 signaling pathway 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
43 HIF-1 signaling pathway 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
44 HIF-1 signaling pathway 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
45 HIF-1 signaling pathway 💬
1件: TFRC 💬 D11812 💬 Pabinafusp alfa 1件: 19 💬
46 HIF-1 signaling pathway 💬
1件: VEGFA 💬 D09574 💬 Aflibercept 2件: 90, 166 💬
47 HIF-1 signaling pathway 💬
1件: VEGFA 💬 D06409 💬 Bevacizumab 9件: 13, 34, 85, 86, 87, 89, 227, 280, 331 💬
48 HIF-1 signaling pathway 💬
1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬