Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 TNF signaling pathway 💬
4件: CCL2, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
2 TNF signaling pathway 💬
1件: CSF1 💬 D06402 💬 Sunitinib 2件: 28, 34 💬
3 TNF signaling pathway 💬
1件: CSF1 💬 D08552 💬 Sunitinib 2件: 28, 34 💬
4 TNF signaling pathway 💬
1件: CSF2 💬 D11343 💬 Otilimab 2件: 46, 256 💬
5 TNF signaling pathway 💬
1件: IL1B 💬 D09315 💬 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
6 TNF signaling pathway 💬
1件: IL1B 💬 D09911 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
7 TNF signaling pathway 💬
1件: IL1B 💬 D06635 💬 Rilonacept 4件: 51, 106, 107, 266 💬
8 TNF signaling pathway 💬
1件: IL6 💬 D09669 💬 Siltuximab 2件: 28, 331 💬
9 TNF signaling pathway 💬
1件: IL6 💬 D10080 💬 Sirukumab 2件: 41, 46 💬
10 TNF signaling pathway 💬
2件: IL6, TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
11 TNF signaling pathway 💬
1件: LTA 💬 D10187 💬 Pateclizumab 1件: 46 💬
12 TNF signaling pathway 💬
2件: LTA, TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
13 TNF signaling pathway 💬
1件: MAP2K1 💬 D10604 💬 Binimetinib 1件: 34 💬
14 TNF signaling pathway 💬
1件: MAP2K1 💬 D10405 💬 Cobimetinib 1件: 280 💬
15 TNF signaling pathway 💬
1件: MAP2K1 💬 D09666 💬 Selumetinib 1件: 34 💬
16 TNF signaling pathway 💬
1件: MAP2K1 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
17 TNF signaling pathway 💬
1件: MAP3K5 💬 D10988 💬 Selonsertib 1件: 86 💬
18 TNF signaling pathway 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
19 TNF signaling pathway 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
20 TNF signaling pathway 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
21 TNF signaling pathway 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
22 TNF signaling pathway 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
23 TNF signaling pathway 💬
1件: PTGS2 💬 D01545 💬 Aceclofenac 1件: 46 💬
24 TNF signaling pathway 💬
1件: PTGS2 💬 D00217 💬 Acetaminophen 18件:  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337 💬
25 TNF signaling pathway 💬
1件: PTGS2 💬 D00109 💬 Acetylsalicylic acid 15件: 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
26 TNF signaling pathway 💬
1件: PTGS2 💬 D00567 💬 Celecoxib 10件:  2 ,  3 , 34, 46, 70, 89, 107, 161, 171, 271 💬
27 TNF signaling pathway 💬
1件: PTGS2 💬 D00903 💬 Diclofenac 5件: 13, 34, 46, 78, 271 💬
28 TNF signaling pathway 💬
1件: PTGS2 💬 D00904 💬 Diclofenac 5件: 13, 34, 46, 78, 271 💬
29 TNF signaling pathway 💬
1件: PTGS2 💬 D07816 💬 Diclofenac 5件: 13, 34, 46, 78, 271 💬
30 TNF signaling pathway 💬
1件: PTGS2 💬 D00130 💬 Diflunisal 1件: 28 💬
31 TNF signaling pathway 💬
1件: PTGS2 💬 D00315 💬 Etodolac 1件: 46 💬
32 TNF signaling pathway 💬
1件: PTGS2 💬 D03710 💬 Etoricoxib 2件: 46, 271 💬
33 TNF signaling pathway 💬
1件: PTGS2 💬 D00330 💬 Flurbiprofen 3件: 13, 21, 46 💬
34 TNF signaling pathway 💬
1件: PTGS2 💬 D01475 💬 Flurbiprofen 3件: 13, 21, 46 💬
35 TNF signaling pathway 💬
1件: PTGS2 💬 D02290 💬 Flurbiprofen 3件: 13, 21, 46 💬
36 TNF signaling pathway 💬
1件: PTGS2 💬 D00126 💬 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299 💬
37 TNF signaling pathway 💬
1件: PTGS2 💬 D01122 💬 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299 💬
38 TNF signaling pathway 💬
1件: PTGS2 💬 D04490 💬 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299 💬
39 TNF signaling pathway 💬
1件: PTGS2 💬 D06606 💬 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299 💬
40 TNF signaling pathway 💬
1件: PTGS2 💬 D00141 💬 Indomethacin 3件: 225, 271, 298 💬
41 TNF signaling pathway 💬
1件: PTGS2 💬 D01565 💬 Indomethacin 3件: 225, 271, 298 💬
42 TNF signaling pathway 💬
1件: PTGS2 💬 D02110 💬 Indomethacin 3件: 225, 271, 298 💬
43 TNF signaling pathway 💬
1件: PTGS2 💬 D00132 💬 Ketoprofen 1件: 46 💬
44 TNF signaling pathway 💬
1件: PTGS2 💬 D00813 💬 Ketorolac 2件: 70, 226 💬
45 TNF signaling pathway 💬
1件: PTGS2 💬 D08104 💬 Ketorolac 2件: 70, 226 💬
46 TNF signaling pathway 💬
1件: PTGS2 💬 D08149 💬 Loxoprofen 2件: 46, 271 💬
47 TNF signaling pathway 💬
1件: PTGS2 💬 D03714 💬 Lumiracoxib 1件: 46 💬
48 TNF signaling pathway 💬
1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
49 TNF signaling pathway 💬
1件: PTGS2 💬 D00118 💬 Naproxen 4件: 13, 46, 107, 271 💬
50 TNF signaling pathway 💬
1件: PTGS2 💬 D01049 💬 Nimesulide 1件: 46 💬
51 TNF signaling pathway 💬
1件: PTGS2 💬 D03716 💬 Parecoxib 2件: 46, 271 💬
52 TNF signaling pathway 💬
1件: PTGS2 💬 D00568 💬 Rofecoxib 1件: 46 💬
53 TNF signaling pathway 💬
1件: PTGS2 💬 D00428 💬 Salsalate 1件:  5  💬
54 TNF signaling pathway 💬
1件: PTGS2 💬 D00120 💬 Sulindac 1件: 206 💬
55 TNF signaling pathway 💬
1件: PTGS2 💬 D01183 💬 Tolfenamic acid 1件:  5  💬
56 TNF signaling pathway 💬
1件: PTGS2 💬 D02709 💬 Valdecoxib 1件: 46 💬
57 TNF signaling pathway 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
58 TNF signaling pathway 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
59 TNF signaling pathway 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
60 TNF signaling pathway 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
61 TNF signaling pathway 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
62 TNF signaling pathway 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
63 TNF signaling pathway 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
64 TNF signaling pathway 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
65 TNF signaling pathway 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬