Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 CETP 1件: Cholesterol metabolism 💬 D08855 Anacetrapib 1件: 79
2 PCSK9 1件: Cholesterol metabolism 💬 D10335 Alirocumab 1件: 79
3 PCSK9 1件: Cholesterol metabolism 💬 D10557 Evolocumab 2件: 79, 222
4 PCSK9 1件: Cholesterol metabolism 💬 D11931 Inclisiran 1件: 79
5 ANGPTL3 1件: Cholesterol metabolism 💬 D11753 Evinacumab 1件: 79
6 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00473 Prednisone 24件: 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
7 NPC1L1 1件: Fat digestion and absorption 💬 D01966 Ezetimibe 3件: 79, 93, 260
8 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D00359 Lovastatin 11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
9 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D00434 Simvastatin 21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
10 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D00887 Atorvastatin 18件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
11 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D00892 Fluvastatin 3件: 79, 218, 222
12 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D00893 Pravastatin 9件: 13, 46, 49, 67, 79, 96, 164, 265, 333
13 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D01915 Rosuvastatin 11件: 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
14 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D07474 Atorvastatin 18件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
15 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D07983 Fluvastatin 3件: 79, 218, 222
16 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D08410 Pravastatin 9件: 13, 46, 49, 67, 79, 96, 164, 265, 333
17 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D08492 Rosuvastatin 11件: 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
18 MTTP 1件: Fat digestion and absorption 💬 D09637 Lomitapide 1件: 79
19 SERPINC1 1件: Complement and coagulation cascades 💬 D07510 Heparin 9件: 79, 84, 107, 224, 226, 280, 299, 316, 317
20 PPARA 10件: PPAR signaling pathway 💬, cAMP signaling pathway 💬, Adipocytokine signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hepatitis C 💬, Chemical carcinogenesis - receptor activation 💬, Diabetic cardiomyopathy 💬 D00565 Fenofibrate 5件: 8, 79, 93, 94, 265