Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Proteoglycans in cancer 💬
1件: BRAF 💬 D10064 💬 Dabrafenib 1件: 34 💬
2 Proteoglycans in cancer 💬
3件: BRAF, KDR, RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
3 Proteoglycans in cancer 💬
3件: BRAF, KDR, RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
4 Proteoglycans in cancer 💬
1件: EGFR 💬 D03455 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
5 Proteoglycans in cancer 💬
1件: EGFR 💬 D04023 💬 Erlotinib 1件: 94 💬
6 Proteoglycans in cancer 💬
1件: EGFR 💬 D07907 💬 Erlotinib 1件: 94 💬
7 Proteoglycans in cancer 💬
1件: EGFR 💬 D01977 💬 Gefitinib 1件: 75 💬
8 Proteoglycans in cancer 💬
1件: EGFR 💬 D11251 💬 Icotinib 1件: 34 💬
9 Proteoglycans in cancer 💬
2件: EGFR, ERBB2 💬 D04024 💬 Lapatinib 3件: 34, 74, 75 💬
10 Proteoglycans in cancer 💬
2件: EGFR, ERBB2 💬 D08108 💬 Lapatinib 3件: 34, 74, 75 💬
11 Proteoglycans in cancer 💬
3件: EGFR, ERBB2, KDR 💬 D11772 💬 Tesevatinib 1件: 67 💬
12 Proteoglycans in cancer 💬
1件: ESR1 💬 D00962 💬 Clomifene 1件: 74 💬
13 Proteoglycans in cancer 💬
1件: ESR1 💬 D07726 💬 Clomifene 1件: 74 💬
14 Proteoglycans in cancer 💬
1件: ESR1 💬 D00289 💬 Danazol 5件: 60, 63, 64, 65, 285 💬
15 Proteoglycans in cancer 💬
1件: ESR1 💬 D02367 💬 Desogestrel 1件: 230 💬
16 Proteoglycans in cancer 💬
1件: ESR1 💬 D11513 💬 Estetrol 1件: 53 💬
17 Proteoglycans in cancer 💬
1件: ESR1 💬 D11514 💬 Estetrol 1件: 53 💬
18 Proteoglycans in cancer 💬
1件: ESR1 💬 D00105 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
19 Proteoglycans in cancer 💬
1件: ESR1 💬 D01413 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
20 Proteoglycans in cancer 💬
1件: ESR1 💬 D01617 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
21 Proteoglycans in cancer 💬
1件: ESR1 💬 D01953 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
22 Proteoglycans in cancer 💬
1件: ESR1 💬 D04061 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
23 Proteoglycans in cancer 💬
1件: ESR1 💬 D04063 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
24 Proteoglycans in cancer 💬
1件: ESR1 💬 D04064 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
25 Proteoglycans in cancer 💬
1件: ESR1 💬 D04065 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
26 Proteoglycans in cancer 💬
1件: ESR1 💬 D01413 💬 Estradiol valerate 1件: 65 💬
27 Proteoglycans in cancer 💬
1件: ESR1 💬 D00185 💬 Estriol 2件: 13, 227 💬
28 Proteoglycans in cancer 💬
1件: ESR1 💬 D01986 💬 Estriol 2件: 13, 227 💬
29 Proteoglycans in cancer 💬
1件: ESR1 💬 D00554 💬 Ethinylestradiol 4件: 13, 46, 49, 299 💬
30 Proteoglycans in cancer 💬
1件: ESR1 💬 D01161 💬 Fulvestrant 2件: 49, 86 💬
31 Proteoglycans in cancer 💬
1件: ESR1 💬 D00575 💬 Mestranol 2件: 46, 49 💬
32 Proteoglycans in cancer 💬
1件: ESR1 💬 D08409 💬 Prasterone 6件: 49, 53, 83, 86, 96, 113 💬
33 Proteoglycans in cancer 💬
1件: ESR1 💬 D02217 💬 Raloxifene 1件: 46 💬
34 Proteoglycans in cancer 💬
1件: ESR1 💬 D08465 💬 Raloxifene 1件: 46 💬
35 Proteoglycans in cancer 💬
1件: ESR1 💬 D00966 💬 Tamoxifen 4件:  2 , 86, 113, 227 💬
36 Proteoglycans in cancer 💬
1件: ESR1 💬 D08559 💬 Tamoxifen 4件:  2 , 86, 113, 227 💬
37 Proteoglycans in cancer 💬
1件: FGFR1 💬 D11589 💬 Infigratinib 1件: 276 💬
38 Proteoglycans in cancer 💬
2件: FGFR1, KDR 💬 D10481 💬 Nintedanib 5件: 51, 85, 89, 227, 228 💬
39 Proteoglycans in cancer 💬
1件: IGF1R 💬 D09925 💬 Linsitinib 1件: 232 💬
40 Proteoglycans in cancer 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
41 Proteoglycans in cancer 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
42 Proteoglycans in cancer 💬
1件: IGF1R 💬 D09680 💬 Teprotumumab 1件: 51 💬
43 Proteoglycans in cancer 💬
1件: IL12B 💬 D09214 💬 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
44 Proteoglycans in cancer 💬
1件: KDR 💬 D03218 💬 Axitinib 1件: 34 💬
45 Proteoglycans in cancer 💬
1件: KDR 💬 D08881 💬 Cediranib 1件: 34 💬
46 Proteoglycans in cancer 💬
1件: KDR 💬 D06402 💬 Sunitinib 2件: 28, 34 💬
47 Proteoglycans in cancer 💬
1件: KDR 💬 D08552 💬 Sunitinib 2件: 28, 34 💬
48 Proteoglycans in cancer 💬
2件: KDR, MET 💬 D10062 💬 Cabozantinib 1件: 34 💬
49 Proteoglycans in cancer 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
50 Proteoglycans in cancer 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
51 Proteoglycans in cancer 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
52 Proteoglycans in cancer 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
53 Proteoglycans in cancer 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
54 Proteoglycans in cancer 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
55 Proteoglycans in cancer 💬
1件: MTOR 💬 D02714 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
56 Proteoglycans in cancer 💬
1件: MTOR 💬 D00753 💬 Sirolimus 41件:  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
57 Proteoglycans in cancer 💬
1件: MTOR 💬 D06068 💬 Temsirolimus 4件: 13, 34, 89, 331 💬
58 Proteoglycans in cancer 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
59 Proteoglycans in cancer 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
60 Proteoglycans in cancer 💬
2件: ROCK1, ROCK2 💬 D07941 💬 Fasudil 4件:  2 ,  5 ,  7 , 51 💬
61 Proteoglycans in cancer 💬
1件: ROCK2 💬 D11815 💬 Belumosudil 1件: 51 💬
62 Proteoglycans in cancer 💬
1件: SMO 💬 D10671 💬 Taladegib 1件: 85 💬
63 Proteoglycans in cancer 💬
1件: SMO 💬 D09992 💬 Vismodegib 1件: 85 💬
64 Proteoglycans in cancer 💬
1件: SRC 💬 D03252 💬 Bosutinib 2件:  2 , 67 💬
65 Proteoglycans in cancer 💬
1件: SRC 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
66 Proteoglycans in cancer 💬
1件: SRC 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
67 Proteoglycans in cancer 💬
1件: SRC 💬 D09664 💬 Saracatinib 3件:  6 , 89, 272 💬
68 Proteoglycans in cancer 💬
2件: TGFB1, TGFB2 💬 D09620 💬 Fresolimumab 4件: 51, 85, 222, 274 💬
69 Proteoglycans in cancer 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
70 Proteoglycans in cancer 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
71 Proteoglycans in cancer 💬
1件: TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
72 Proteoglycans in cancer 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
73 Proteoglycans in cancer 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
74 Proteoglycans in cancer 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
75 Proteoglycans in cancer 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
76 Proteoglycans in cancer 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
77 Proteoglycans in cancer 💬
1件: TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
78 Proteoglycans in cancer 💬
1件: TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
79 Proteoglycans in cancer 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
80 Proteoglycans in cancer 💬
1件: VEGFA 💬 D09574 💬 Aflibercept 2件: 90, 166 💬
81 Proteoglycans in cancer 💬
1件: VEGFA 💬 D06409 💬 Bevacizumab 9件: 13, 34, 85, 86, 87, 89, 227, 280, 331 💬
82 Proteoglycans in cancer 💬
1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬