Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Ras signaling pathway 💬
1件: ABL1 💬 D03252 💬 Bosutinib 2件:  2 , 67 💬
2 Ras signaling pathway 💬
1件: ABL1 💬 D09664 💬 Saracatinib 3件:  6 , 89, 272 💬
3 Ras signaling pathway 💬
4件: ABL1, EPHA2, KIT, PDGFRB 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
4 Ras signaling pathway 💬
4件: ABL1, EPHA2, KIT, PDGFRB 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
5 Ras signaling pathway 💬
3件: ABL1, KIT, PDGFRA 💬 D01441 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
6 Ras signaling pathway 💬
3件: ABL1, KIT, PDGFRA 💬 D08066 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
7 Ras signaling pathway 💬
4件: ABL1, KIT, PDGFRA, PDGFRB 💬 D08953 💬 Nilotinib 5件:  6 ,  8 , 34, 51, 86 💬
8 Ras signaling pathway 💬
8件: CSF1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 D06402 💬 Sunitinib 2件: 28, 34 💬
9 Ras signaling pathway 💬
8件: CSF1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 D08552 💬 Sunitinib 2件: 28, 34 💬
10 Ras signaling pathway 💬
3件: CSF1R, FLT3, KIT 💬 D11270 💬 Pexidartinib 1件: 34 💬
11 Ras signaling pathway 💬
1件: EGFR 💬 D03455 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
12 Ras signaling pathway 💬
1件: EGFR 💬 D04023 💬 Erlotinib 1件: 94 💬
13 Ras signaling pathway 💬
1件: EGFR 💬 D07907 💬 Erlotinib 1件: 94 💬
14 Ras signaling pathway 💬
1件: EGFR 💬 D01977 💬 Gefitinib 1件: 75 💬
15 Ras signaling pathway 💬
1件: EGFR 💬 D11251 💬 Icotinib 1件: 34 💬
16 Ras signaling pathway 💬
1件: EGFR 💬 D04024 💬 Lapatinib 3件: 34, 74, 75 💬
17 Ras signaling pathway 💬
1件: EGFR 💬 D08108 💬 Lapatinib 3件: 34, 74, 75 💬
18 Ras signaling pathway 💬
3件: EGFR, FLT4, KDR 💬 D11772 💬 Tesevatinib 1件: 67 💬
19 Ras signaling pathway 💬
1件: FGF23 💬 D10913 💬 Burosumab 1件: 238 💬
20 Ras signaling pathway 💬
3件: FGFR1, FGFR2, FGFR3 💬 D11589 💬 Infigratinib 1件: 276 💬
21 Ras signaling pathway 💬
8件: FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 D10481 💬 Nintedanib 5件: 51, 85, 89, 227, 228 💬
22 Ras signaling pathway 💬
1件: FGFR2 💬 D05338 💬 Palifermin 5件: 13, 36, 38, 39, 65 💬
23 Ras signaling pathway 💬
3件: FLT1, FLT4, KDR 💬 D03218 💬 Axitinib 1件: 34 💬
24 Ras signaling pathway 💬
3件: FLT1, FLT4, KDR 💬 D08881 💬 Cediranib 1件: 34 💬
25 Ras signaling pathway 💬
6件: FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
26 Ras signaling pathway 💬
6件: FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
27 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D02780 💬 Acamprosate 2件:  6 , 206 💬
28 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D07058 💬 Acamprosate 2件:  6 , 206 💬
29 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D00777 💬 Amantadine 4件:  6 ,  8 , 13, 127 💬
30 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D07441 💬 Amantadine 4件:  6 ,  8 , 13, 127 💬
31 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D00848 💬 Dextromethorphan 11件:  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
32 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D03742 💬 Dextromethorphan 11件:  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
33 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D03744 💬 Dextromethorphan 11件:  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
34 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D07283 💬 Esketamine 3件:  2 ,  4 , 70 💬
35 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D00711 💬 Ketamine 8件:  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
36 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D08098 💬 Ketamine 8件:  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
37 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D09917 💬 Latrepirdine 1件:  8  💬
38 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D04905 💬 Memantine 7件:  2 ,  6 ,  8 , 13, 49, 127, 205 💬
39 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D08174 💬 Memantine 7件:  2 ,  6 ,  8 , 13, 49, 127, 205 💬
40 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
41 Ras signaling pathway 💬
1件: IGF1R 💬 D09925 💬 Linsitinib 1件: 232 💬
42 Ras signaling pathway 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
43 Ras signaling pathway 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
44 Ras signaling pathway 💬
1件: IGF1R 💬 D09680 💬 Teprotumumab 1件: 51 💬
45 Ras signaling pathway 💬
1件: INSR 💬 D04539 💬 Insulin detemir 1件: 299 💬
46 Ras signaling pathway 💬
1件: INSR 💬 D03250 💬 Insulin glargine 1件: 299 💬
47 Ras signaling pathway 💬
1件: INSR 💬 D00085 💬 Insulin human 2件: 96, 156 💬
48 Ras signaling pathway 💬
1件: INSR 💬 D03230 💬 Insulin human 2件: 96, 156 💬
49 Ras signaling pathway 💬
2件: KDR, MET 💬 D10062 💬 Cabozantinib 1件: 34 💬
50 Ras signaling pathway 💬
1件: KIT 💬 D10229 💬 Masitinib 6件:  2 ,  5 ,  6 , 13, 46, 96 💬
51 Ras signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
52 Ras signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
53 Ras signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
54 Ras signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
55 Ras signaling pathway 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
56 Ras signaling pathway 💬
1件: NGF 💬 D09387 💬 Tanezumab 2件: 226, 298 💬
57 Ras signaling pathway 💬
1件: NGFR 💬 D11028 💬 Cenegermin 2件: 53, 90 💬
58 Ras signaling pathway 💬
3件: PGF, VEGFA, VEGFB 💬 D09574 💬 Aflibercept 2件: 90, 166 💬
59 Ras signaling pathway 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
60 Ras signaling pathway 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
61 Ras signaling pathway 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
62 Ras signaling pathway 💬
1件: VEGFA 💬 D06409 💬 Bevacizumab 9件: 13, 34, 85, 86, 87, 89, 227, 280, 331 💬
63 Ras signaling pathway 💬
1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬