Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 CFTR [6] cAMP signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection D09916 Ivacaftor [1] 299
2 CFTR [6] cAMP signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection D10134 Lumacaftor [1] 299
3 CFTR [6] cAMP signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection D11041 Tezacaftor [1] 299
4 CFTR [6] cAMP signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection D11423 Deutivacaftor [1] 299
5 CFTR [6] cAMP signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection D11507 Elexacaftor [1] 299
6 CFTR [6] cAMP signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection D11724 Galicaftor [1] 299
7 HMGCR [3] Terpenoid backbone biosynthesis, Metabolic pathways, Bile secretion D00359 Lovastatin [11] 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
8 HMGCR [3] Terpenoid backbone biosynthesis, Metabolic pathways, Bile secretion D00434 Simvastatin [21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
9 HMGCR [3] Terpenoid backbone biosynthesis, Metabolic pathways, Bile secretion D07474 Atorvastatin [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299
10 HMGCR [3] Terpenoid backbone biosynthesis, Metabolic pathways, Bile secretion D07983 Fluvastatin [3] 79, 218, 222
11 HMGCR [3] Terpenoid backbone biosynthesis, Metabolic pathways, Bile secretion D08410 Pravastatin [9] 13, 46, 49, 67, 79, 96, 164, 265, 333
12 HMGCR [3] Terpenoid backbone biosynthesis, Metabolic pathways, Bile secretion D08492 Rosuvastatin [11] 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
13 ATP1A1 [15] cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00297 Digitoxin [1] 299
14 ATP1A1 [15] cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00298 Digoxin [3] 8, 46, 210
15 ATP1A2 [15] cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00297 Digitoxin [1] 299
16 ATP1A2 [15] cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00298 Digoxin [3] 8, 46, 210
17 ATP1A3 [15] cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00297 Digitoxin [1] 299
18 ATP1A3 [15] cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00298 Digoxin [3] 8, 46, 210
19 ATP1A4 [15] cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00297 Digitoxin [1] 299
20 ATP1A4 [15] cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00298 Digoxin [3] 8, 46, 210
21 RXRA [16] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease, Bile secretion, Hepatitis C, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis D02754 Acitretin [1] 37
22 RXRA [16] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease, Bile secretion, Hepatitis C, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis D02815 Alitretinoin [1] 49
23 RXRA [16] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease, Bile secretion, Hepatitis C, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis D03106 Bexarotene [2] 13, 75
24 SLC10A1 [2] Bile secretion, Hepatitis B D10951 Maralixibat [3] 296, 297, 338
25 SLC10A2 [1] Bile secretion D10796 Elobixibat [1] 6
26 SLC10A2 [1] Bile secretion D10951 Maralixibat [3] 296, 297, 338
27 SLC10A2 [1] Bile secretion D11716 Odevixibat [3] 296, 297, 338
28 CA2 [7] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
29 CA2 [7] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion D00518 Diclofenamide [1] 114
30 CA2 [7] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
31 CA2 [7] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion D07871 Dorzolamide [1] 90
32 NR1H4 [1] Bile secretion D00163 Chenodeoxycholic acid [4] 20, 96, 234, 263
33 NR1H4 [1] Bile secretion D00734 Ursodeoxycholic acid [14] 6, 8, 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299
34 NR1H4 [1] Bile secretion D09360 Obeticholic acid [3] 93, 265, 296
35 NR1H4 [1] Bile secretion D10699 Cholic Acid [4] 20, 234, 265, 310
36 NR1H4 [1] Bile secretion D11548 Tropifexor [1] 93