Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 MAPK signaling pathway 💬
1件: BRAF 💬 D10064 💬 Dabrafenib 1件: 34 💬
2 MAPK signaling pathway 💬
7件: BRAF, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
3 MAPK signaling pathway 💬
7件: BRAF, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
4 MAPK signaling pathway 💬
5件: CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine 1件: 67 💬
5 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00615 💬 Amlodipine 4件: 13, 51, 67, 298 💬
6 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02914 💬 Amlodipine 4件: 13, 51, 67, 298 💬
7 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine 4件: 13, 51, 67, 298 💬
8 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00616 💬 Diltiazem 3件: 51, 58, 86 💬
9 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D03830 💬 Diltiazem 3件: 51, 58, 86 💬
10 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem 3件: 51, 58, 86 💬
11 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine 1件:  6  💬
12 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00617 💬 Nicardipine 2件: 70, 86 💬
13 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine 2件: 70, 86 💬
14 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine 2件: 50, 81 💬
15 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine 1件: 90 💬
16 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D05442 💬 Perhexiline 2件: 58, 272 💬
17 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline 2件: 58, 272 💬
18 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08441 💬 Propiverine 1件: 226 💬
19 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
20 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00619 💬 Verapamil 3件: 96, 140, 167 💬
21 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil 3件: 96, 140, 167 💬
22 MAPK signaling pathway 💬
3件: CACNA1G, CACNA1H, CACNA1I 💬 D01303 💬 Flunarizine 4件: 58, 86, 149, 215 💬
23 MAPK signaling pathway 💬
3件: CACNA1G, CACNA1H, CACNA1I 💬 D07971 💬 Flunarizine 4件: 58, 86, 149, 215 💬
24 MAPK signaling pathway 💬
3件: CACNA1G, CACNA1H, CACNA1I 💬 D00399 💬 Valproic acid 17件:  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331 💬
25 MAPK signaling pathway 💬
3件: CACNA1G, CACNA1H, CACNA1I 💬 D00538 💬 Zonisamide 1件:  6  💬
26 MAPK signaling pathway 💬
2件: CACNA2D1, CACNA2D2 💬 D11203 💬 Mirogabalin 1件: 70 💬
27 MAPK signaling pathway 💬
4件: CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 D00332 💬 Gabapentin 5件:  6 , 13, 19, 70, 298 💬
28 MAPK signaling pathway 💬
4件: CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 D02716 💬 Pregabalin 5件: 13, 36, 46, 70, 298 💬
29 MAPK signaling pathway 💬
8件: CSF1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 D06402 💬 Sunitinib 2件: 28, 34 💬
30 MAPK signaling pathway 💬
8件: CSF1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 D08552 💬 Sunitinib 2件: 28, 34 💬
31 MAPK signaling pathway 💬
3件: CSF1R, FLT3, KIT 💬 D11270 💬 Pexidartinib 1件: 34 💬
32 MAPK signaling pathway 💬
1件: EGFR 💬 D03455 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
33 MAPK signaling pathway 💬
1件: EGFR 💬 D04023 💬 Erlotinib 1件: 94 💬
34 MAPK signaling pathway 💬
1件: EGFR 💬 D07907 💬 Erlotinib 1件: 94 💬
35 MAPK signaling pathway 💬
1件: EGFR 💬 D01977 💬 Gefitinib 1件: 75 💬
36 MAPK signaling pathway 💬
1件: EGFR 💬 D11251 💬 Icotinib 1件: 34 💬
37 MAPK signaling pathway 💬
2件: EGFR, ERBB2 💬 D04024 💬 Lapatinib 3件: 34, 74, 75 💬
38 MAPK signaling pathway 💬
2件: EGFR, ERBB2 💬 D08108 💬 Lapatinib 3件: 34, 74, 75 💬
39 MAPK signaling pathway 💬
4件: EGFR, ERBB2, FLT4, KDR 💬 D11772 💬 Tesevatinib 1件: 67 💬
40 MAPK signaling pathway 💬
3件: EPHA2, KIT, PDGFRB 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
41 MAPK signaling pathway 💬
3件: EPHA2, KIT, PDGFRB 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
42 MAPK signaling pathway 💬
1件: FGF23 💬 D10913 💬 Burosumab 1件: 238 💬
43 MAPK signaling pathway 💬
3件: FGFR1, FGFR2, FGFR3 💬 D11589 💬 Infigratinib 1件: 276 💬
44 MAPK signaling pathway 💬
8件: FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 D10481 💬 Nintedanib 5件: 51, 85, 89, 227, 228 💬
45 MAPK signaling pathway 💬
1件: FGFR2 💬 D05338 💬 Palifermin 5件: 13, 36, 38, 39, 65 💬
46 MAPK signaling pathway 💬
3件: FLT1, FLT4, KDR 💬 D03218 💬 Axitinib 1件: 34 💬
47 MAPK signaling pathway 💬
3件: FLT1, FLT4, KDR 💬 D08881 💬 Cediranib 1件: 34 💬
48 MAPK signaling pathway 💬
1件: IGF1R 💬 D09925 💬 Linsitinib 1件: 232 💬
49 MAPK signaling pathway 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
50 MAPK signaling pathway 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
51 MAPK signaling pathway 💬
1件: IGF1R 💬 D09680 💬 Teprotumumab 1件: 51 💬
52 MAPK signaling pathway 💬
1件: IL1A 💬 D11253 💬 Bermekimab 1件: 51 💬
53 MAPK signaling pathway 💬
2件: IL1A, IL1B 💬 D06635 💬 Rilonacept 4件: 51, 106, 107, 266 💬
54 MAPK signaling pathway 💬
3件: IL1A, IL1B, TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
55 MAPK signaling pathway 💬
1件: IL1B 💬 D09315 💬 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
56 MAPK signaling pathway 💬
1件: IL1B 💬 D09911 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
57 MAPK signaling pathway 💬
1件: IL1R1 💬 D02934 💬 Anakinra 19件:  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
58 MAPK signaling pathway 💬
1件: INSR 💬 D04539 💬 Insulin detemir 1件: 299 💬
59 MAPK signaling pathway 💬
1件: INSR 💬 D03250 💬 Insulin glargine 1件: 299 💬
60 MAPK signaling pathway 💬
1件: INSR 💬 D00085 💬 Insulin human 2件: 96, 156 💬
61 MAPK signaling pathway 💬
1件: INSR 💬 D03230 💬 Insulin human 2件: 96, 156 💬
62 MAPK signaling pathway 💬
2件: KDR, MET 💬 D10062 💬 Cabozantinib 1件: 34 💬
63 MAPK signaling pathway 💬
1件: KIT 💬 D10229 💬 Masitinib 6件:  2 ,  5 ,  6 , 13, 46, 96 💬
64 MAPK signaling pathway 💬
2件: KIT, PDGFRA 💬 D01441 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
65 MAPK signaling pathway 💬
2件: KIT, PDGFRA 💬 D08066 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
66 MAPK signaling pathway 💬
3件: KIT, PDGFRA, PDGFRB 💬 D08953 💬 Nilotinib 5件:  6 ,  8 , 34, 51, 86 💬
67 MAPK signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
68 MAPK signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
69 MAPK signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
70 MAPK signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
71 MAPK signaling pathway 💬
1件: MAP3K5 💬 D10988 💬 Selonsertib 1件: 86 💬
72 MAPK signaling pathway 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
73 MAPK signaling pathway 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
74 MAPK signaling pathway 💬
1件: MAPT 💬 D11210 💬 Flortaucipir 3件:  5 ,  7 , 127 💬
75 MAPK signaling pathway 💬
1件: MAPT 💬 D11293 💬 Gosuranemab 1件:  5  💬
76 MAPK signaling pathway 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
77 MAPK signaling pathway 💬
1件: NGF 💬 D09387 💬 Tanezumab 2件: 226, 298 💬
78 MAPK signaling pathway 💬
1件: NGFR 💬 D11028 💬 Cenegermin 2件: 53, 90 💬
79 MAPK signaling pathway 💬
3件: PGF, VEGFA, VEGFB 💬 D09574 💬 Aflibercept 2件: 90, 166 💬
80 MAPK signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
81 MAPK signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus 1件: 160 💬
82 MAPK signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
83 MAPK signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
84 MAPK signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin 1件: 222 💬
85 MAPK signaling pathway 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
86 MAPK signaling pathway 💬
3件: TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab 4件: 51, 85, 222, 274 💬
87 MAPK signaling pathway 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
88 MAPK signaling pathway 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
89 MAPK signaling pathway 💬
1件: TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
90 MAPK signaling pathway 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
91 MAPK signaling pathway 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
92 MAPK signaling pathway 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
93 MAPK signaling pathway 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
94 MAPK signaling pathway 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
95 MAPK signaling pathway 💬
1件: TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
96 MAPK signaling pathway 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
97 MAPK signaling pathway 💬
1件: VEGFA 💬 D06409 💬 Bevacizumab 9件: 13, 34, 85, 86, 87, 89, 227, 280, 331 💬
98 MAPK signaling pathway 💬
1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬