Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Acetate [1] Acetate---[41] 1, 2, 6, 10, 13, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 171, 206, 222, 224, 225, 227, 235, 251, 265, 288, 298, 299 💬
2 Albendazole [2] Albendazole; Eskazole[1] Albendazole 💬--[12] 5, 6, 7, 13, 28, 51, 67, 86, 96, 97, 114, 127 💬
3 Amiloride [3] Amiloride; Amiloride Hydrochloride; Midamor[1] Amiloride 💬[3] SCNN1A,
SCNN1B,
SCNN1G 💬		[2] Aldosterone-regulated sodium reabsorption, Taste transduction 💬[4] 13, 67, 225, 299 💬
4 Aminohippuric acid [1] Aminohippurate[1] Aminohippuric acid 💬--[4] 49, 53, 67, 86 💬
5 Amlodipine [1] Amlodipine[1] Amlodipine 💬[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 13, 51, 67, 298 💬
6 Arginine [6] Arginina; Arginine; L-Arg; L-Arginin; L-arginine; R-Gene[1] Arginine 💬--[12] 46, 58, 65, 67, 78, 96, 97, 98, 113, 210, 251, 299 💬
7 Aspartame [0] [1] Aspartame 💬[2] TAS1R2,
TAS1R3 💬		[2] Carbohydrate digestion and absorption, Taste transduction 💬[4] 6, 13, 67, 86 💬
8 Bardoxolone [1] Bardoxolone[1] Bardoxolone 💬--[7] 66, 67, 84, 85, 86, 218, 222 💬
9 Bardoxolone methyl [1] Bardoxolone methyl[1] Bardoxolone methyl 💬--[7] 66, 67, 84, 85, 86, 218, 222 💬
10 Bendroflumethiazide [1] BENDROFLUMETHIAZIDE[1] Bendroflumethiazide 💬[1] SLC12A3 💬-[1] 67 💬
11 Bisoprolol [2] Bisoprolol; Bisoprolol Fumarate[1] Bisoprolol 💬[1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 58, 67, 86, 113 💬
12 Bosutinib [1] Bosutinib[1] Bosutinib 💬[2] ABL1,
SRC 💬		[49] Adherens junction, Axon guidance, Bacterial invasion of epithelial cells, Bladder cancer, C-type lectin receptor signaling pathway, Cell cycle, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Fluid shear stress and atherosclerosis, Focal adhesion, GABAergic synapse, Gap junction, GnRH signaling pathway, Hepatitis B, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, MicroRNAs in cancer, Mitophagy - animal, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Platelet activation, Prolactin signaling pathway, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Thyroid hormone signaling pathway, Tight junction, Tuberculosis, VEGF signaling pathway, Viral carcinogenesis, Viral myocarditis, Yersinia infection 💬[2] 2, 67 💬
13 Candesartan [1] Candesartan[1] Candesartan 💬[1] AGTR1 💬[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 58, 67 💬
14 Candesartan cilexetil [1] CANDESARTAN[1] Candesartan cilexetil 💬[1] AGTR1 💬[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 67 💬
15 Chloride ion [1] Chloride---[28] 6, 11, 13, 14, 34, 41, 46, 50, 51, 53, 60, 67, 70, 96, 97, 107, 127, 168, 171, 193, 227, 228, 251, 288, 296, 297, 299, 338 💬
16 Cilnidipine [1] Cilnidipine[1] Cilnidipine 💬[5] CACNA1B,
CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[41] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Huntington disease, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Morphine addiction, Nicotine addiction, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 67 💬
17 Curcumin [1] Curcumin---[10] 2, 13, 46, 67, 74, 94, 96, 97, 139, 299 💬
18 Dapagliflozin [2] Dapagliflozin; Forxiga[1] Dapagliflozin 💬[1] SLC5A2 💬-[7] 19, 49, 66, 67, 86, 88, 222 💬
19 Doxazosin [2] CARDURA; Doxazosin[1] Doxazosin 💬[3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 57, 67 💬
20 Emodin [1] Emodin---[1] 67 💬
21 Empagliflozin [2] Empagliflozin; Jardiance[1] Empagliflozin 💬[1] SLC5A2 💬-[6] 58, 65, 67, 72, 97, 257 💬
22 Everolimus [4] Afinitor; Certican; Everolimus; Votubia[1] Everolimus 💬[1] MTOR 💬[51] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
23 Hydralazine [1] Hydralazine[1] Hydralazine 💬[1] AOC3 💬[5] Glycine, serine and threonine metabolism, Metabolic pathways, Phenylalanine metabolism, Tyrosine metabolism, beta-Alanine metabolism 💬[1] 67 💬
24 Hydrochlorothiazide [2] Esidrix; HYDROCHLOROTHIAZIDE[1] Hydrochlorothiazide 💬[1] SLC12A3 💬-[4] 13, 67, 225, 235 💬
25 Imidapril [1] Imidapril[1] Imidapril 💬[1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[1] 67 💬
26 Iohexol [2] Iohexol; OMNIPAQUE[1] Iohexol 💬--[3] 19, 67, 222 💬
27 L-arginine [1] L-arginine[1] Arginine 💬--[8] 46, 67, 78, 96, 97, 98, 113, 299 💬
28 Lanreotide [3] Lanreotide; LANREOTIDE ACETATE; Somatuline Autogel---[4] 67, 73, 85, 298 💬
29 Leuprolide [3] Leuprolide; Leuprolide acetate depot; Leuprorelin---[6] 1, 2, 3, 51, 67, 76 💬
30 Lisinopril [2] Lisinopril; Zestril[2] Lisinopril ,
Lisinopril 💬		[1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[7] 19, 46, 49, 66, 67, 113, 222 💬
31 Lixivaptan [1] Lixivaptan[1] Lixivaptan 💬[1] AVPR2 💬[3] Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬[1] 67 💬
32 Losartan [3] Cozaar; Losartan; LOSARTAN POTASSIUM[1] Losartan 💬[1] AGTR1 💬[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
33 Metformin [5] Metformin; Metformin HCl; METFORMIN HYDROCHLORIDE; METFORMINA; Metformine[1] Metformin 💬[2] PRKAA1,
PRKAA2 💬		[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬[25] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
34 Nicotinamide [3] Multivitamin; Niacinamide; Nicotinamide[1] Niacinamide 💬--[10] 2, 5, 6, 18, 49, 67, 97, 107, 162, 191 💬
35 Nitrate [1] Nitrate[1] Nitric acid 💬--[4] 58, 67, 113, 299 💬
36 Octreotide [3] Octreotide; OCTREOTIDE ACETATE; Sandostatin LAR[1] Octreotide 💬[1] SSTR2 💬[4] Gastric acid secretion, Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[7] 67, 75, 84, 85, 89, 193, 227 💬
37 Pasireotide [3] Pasireotida; Pasireotide; SIGNIFOR[1] Pasireotide 💬[4] SSTR1,
SSTR2,
SSTR3,
SSTR5 💬		[4] Gastric acid secretion, Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[3] 67, 74, 75 💬
38 Pioglitazone [1] Pioglitazone[1] Pioglitazone 💬[1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
39 Potassium [1] Potassium[1] Potassium 💬--[13] 36, 46, 66, 67, 88, 93, 94, 98, 115, 167, 179, 215, 235 💬
40 Pravastatin [2] Pravastatin; Pravastatin sodium[1] Pravastatin 💬[1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
41 Ramipril [1] Ramipril[1] Ramipril 💬[1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[7] 46, 49, 66, 67, 113, 218, 257 💬
42 Sirolimus [3] Rapamune; Rapamycin; Sirolimus[1] Sirolimus 💬[1] MTOR 💬[51] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬[40] 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
43 Sodium chloride [6] Lactated Ringers; Natriumchlorid; REBIF; Saline; SODIUM CHLORIDE; SPORANOX[1] Sodium chloride 💬--[20] 6, 11, 13, 14, 34, 41, 46, 50, 51, 53, 60, 67, 70, 96, 168, 193, 227, 228, 288, 299 💬
44 Sodium citrate [1] Sodium citrate[2] Sodium citrate hydrate ,
Sodium citrate 💬		--[4] 67, 214, 215, 235 💬
45 Somatostatin [1] Somatostatin[1] Somatostatin 💬[5] SSTR1,
SSTR2,
SSTR3,
SSTR4,
SSTR5 💬		[4] Gastric acid secretion, Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[2] 67, 78 💬
46 Spironolactone [1] Spironolactone[1] Spironolactone 💬[1] NR3C2 💬[1] Aldosterone-regulated sodium reabsorption 💬[8] 46, 58, 67, 86, 113, 210, 218, 225 💬
47 Telmisartan [1] Telmisartan[1] Telmisartan 💬[1] AGTR1 💬[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 66, 67 💬
48 Tesevatinib [1] Tesevatinib[1] Tesevatinib 💬[5] EGFR,
EPHB4,
ERBB2,
FLT4,
KDR 💬		[53] Adherens junction, Axon guidance, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Fluid shear stress and atherosclerosis, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Platinum drug resistance, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Tight junction, VEGF signaling pathway 💬[1] 67 💬
49 Tilarginine [1] NG-Monomethyl-L-arginine---[1] 67 💬
50 Tolvaptan [3] Jinarc; Samsca; TOLVAPTAN[1] Tolvaptan 💬[1] AVPR2 💬[3] Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬[4] 67, 72, 86, 225 💬
51 Tripterygium wilfordii whole [2] Tripterygium; Tripterygium Wilfordii---[8] 46, 66, 67, 96, 162, 222, 224, 271 💬
52 Triptolide [1] Triptolide---[1] 67 💬
53 Ursodeoxycholic acid [4] UDCA; Ursodeoxycholic acid; Ursodiol; Ursofalk[1] Ursodiol 💬[1] NR1H4 💬[1] Bile secretion 💬[14] 6, 8, 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬
54 Venglustat [2] GENZ-682452; Venglustat[1] Venglustat 💬[1] UGCG 💬[2] Metabolic pathways, Sphingolipid metabolism 💬[3] 6, 19, 67 💬
55 Water [8] AVONEX; ENBREL; Hiberix; Indocyanine green; OMNITROPE; Sterile Water for Injection; Water; WATER FOR INJECTION[1] Water 💬--[21] 2, 5, 6, 13, 17, 22, 35, 46, 53, 57, 63, 65, 67, 78, 84, 96, 97, 206, 226, 278, 299 💬