Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 SIGMAR1 💬 [2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases Dextromethorphan 💬 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
2 SIGMAR1 💬 [2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
3 SIGMAR1 💬 [2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases Blarcamesine 💬 Blarcamesine [1] 156 💬
4 SLC22A12 💬 - Benzbromarone 💬 Benzbromarone [1] 86 💬
5 S1PR1 💬 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Fingolimod 💬 Fingolimod [3] 13, 14, 156 💬
6 S1PR1 💬 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Amiselimod 💬 Amiselimod [1] 97 💬
7 S1PR1 💬 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Etrasimod 💬 Etrasimod [3] 96, 97, 98 💬
8 S1PR1 💬 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Ozanimod 💬 Ozanimod [3] 13, 96, 97 💬
9 S1PR1 💬 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Ponesimod 💬 Ponesimod [1] 13 💬
10 S1PR1 💬 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Cenerimod 💬 Cenerimod [1] 49 💬
11 S1PR1 💬 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Siponimod 💬 Siponimod [2] 13, 50 💬
12 S1PR3 💬 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Amiselimod 💬 Amiselimod [1] 97 💬
13 S1PR3 💬 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Etrasimod 💬 Etrasimod [3] 96, 97, 98 💬
14 S1PR3 💬 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Ozanimod 💬 Ozanimod [3] 13, 96, 97 💬
15 SV2C 💬 [1] ECM-receptor interaction Padsevonil 💬 Padsevonil [1] 149 💬
16 SIGLEC8 💬 - Lirentelimab 💬 Lirentelimab [1] 98 💬
17 SERPIND1 💬 [1] Complement and coagulation cascades Sulodexide 💬 Sulodexide [2] 51, 271 💬
18 SMAD7 💬 [2] TGF-beta signaling pathway, Hippo signaling pathway Mongersen 💬 Mongersen [2] 96, 97 💬
19 SERPINC1 💬 [1] Complement and coagulation cascades Adomiparin 💬 Heparin [11] 47, 60, 70, 84, 107, 224, 226, 280, 299, 316, 317 💬
20 SERPINC1 💬 [1] Complement and coagulation cascades Adomiparin 💬 Enoxaparin [1] 46 💬
21 SERPINC1 💬 [1] Complement and coagulation cascades Adomiparin 💬 Parnaparin [1] 97 💬
22 SERPINC1 💬 [1] Complement and coagulation cascades Sulodexide 💬 Sulodexide [2] 51, 271 💬
23 SOST 💬 [2] Wnt signaling pathway, Parathyroid hormone synthesis, secretion and action Romosozumab 💬 Romosozumab [1] 274 💬
24 S1PR5 💬 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Amiselimod 💬 Amiselimod [1] 97 💬
25 S1PR5 💬 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Etrasimod 💬 Etrasimod [3] 96, 97, 98 💬
26 S1PR5 💬 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Ozanimod 💬 Ozanimod [3] 13, 96, 97 💬
27 S1PR5 💬 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Siponimod 💬 Siponimod [2] 13, 50 💬
28 SLAMF7 💬 - Elotuzumab 💬 Elotuzumab [1] 28 💬
29 SORT1 💬 [3] Lysosome, Neurotrophin signaling pathway, Cholesterol metabolism Latozinemab 💬 Latozinemab [2] 2, 127 💬
30 SCN1A 💬 [1] Dopaminergic synapse Carbamazepine 💬 Carbamazepine [3] 6, 13, 231 💬
31 SCN1A 💬 [1] Dopaminergic synapse Lamotrigine 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬
32 SCN1A 💬 [1] Dopaminergic synapse Lidocaine 💬 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
33 SCN1A 💬 [1] Dopaminergic synapse Phenytoin 💬 Phenytoin [1] 13 💬
34 SCN1A 💬 [1] Dopaminergic synapse Oxcarbazepine 💬 Oxcarbazepine [1] 13 💬
35 SCN1A 💬 [1] Dopaminergic synapse Topiramate 💬 Topiramate [6] 6, 97, 140, 144, 156, 193 💬
36 SCN1A 💬 [1] Dopaminergic synapse Zonisamide 💬 Zonisamide [1] 6 💬
37 SCN1A 💬 [1] Dopaminergic synapse Amiodarone 💬 Amiodarone [2] 28, 127 💬
38 SCN1A 💬 [1] Dopaminergic synapse Cifenline 💬 Cibenzoline [1] 58 💬
39 SCN1A 💬 [1] Dopaminergic synapse Rufinamide 💬 Rufinamide [1] 144 💬
40 SCN1A 💬 [1] Dopaminergic synapse Bupivacaine 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
41 SCN1A 💬 [1] Dopaminergic synapse Flecainide 💬 Flecainide [1] 6 💬
42 SCN1A 💬 [1] Dopaminergic synapse Levobupivacaine 💬 Levobupivacaine [1] 46 💬
43 SCN1A 💬 [1] Dopaminergic synapse Lidocaine hydrochloride monohydrate 💬 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
44 SCN1A 💬 [1] Dopaminergic synapse Mexiletine 💬 Mexiletine [5] 1, 2, 10, 113, 114 💬
45 SCN1A 💬 [1] Dopaminergic synapse Oxybuprocaine 💬 Oxybuprocaine [1] 6 💬
46 SCN1A 💬 [1] Dopaminergic synapse Quinidine 💬 Quinidine [3] 2, 8, 13 💬
47 SCN1A 💬 [1] Dopaminergic synapse Ropivacaine 💬 Ropivacaine [4] 22, 36, 46, 70 💬
48 SCN1A 💬 [1] Dopaminergic synapse Eleclazine 💬 Eleclazine [1] 58 💬
49 SCN2A 💬 [1] Taste transduction Carbamazepine 💬 Carbamazepine [3] 6, 13, 231 💬
50 SCN2A 💬 [1] Taste transduction Lamotrigine 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬
51 SCN2A 💬 [1] Taste transduction Lidocaine 💬 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
52 SCN2A 💬 [1] Taste transduction Phenytoin 💬 Phenytoin [1] 13 💬
53 SCN2A 💬 [1] Taste transduction Oxcarbazepine 💬 Oxcarbazepine [1] 13 💬
54 SCN2A 💬 [1] Taste transduction Topiramate 💬 Topiramate [6] 6, 97, 140, 144, 156, 193 💬
55 SCN2A 💬 [1] Taste transduction Zonisamide 💬 Zonisamide [1] 6 💬
56 SCN2A 💬 [1] Taste transduction Amiodarone 💬 Amiodarone [2] 28, 127 💬
57 SCN2A 💬 [1] Taste transduction Cifenline 💬 Cibenzoline [1] 58 💬
58 SCN2A 💬 [1] Taste transduction Rufinamide 💬 Rufinamide [1] 144 💬
59 SCN2A 💬 [1] Taste transduction Bupivacaine 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
60 SCN2A 💬 [1] Taste transduction Flecainide 💬 Flecainide [1] 6 💬
61 SCN2A 💬 [1] Taste transduction Levobupivacaine 💬 Levobupivacaine [1] 46 💬
62 SCN2A 💬 [1] Taste transduction Lidocaine hydrochloride monohydrate 💬 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
63 SCN2A 💬 [1] Taste transduction Mexiletine 💬 Mexiletine [5] 1, 2, 10, 113, 114 💬
64 SCN2A 💬 [1] Taste transduction Oxybuprocaine 💬 Oxybuprocaine [1] 6 💬
65 SCN2A 💬 [1] Taste transduction Quinidine 💬 Quinidine [3] 2, 8, 13 💬
66 SCN2A 💬 [1] Taste transduction Ropivacaine 💬 Ropivacaine [4] 22, 36, 46, 70 💬
67 SCN2A 💬 [1] Taste transduction Eleclazine 💬 Eleclazine [1] 58 💬
68 SCN3A 💬 [1] Taste transduction Carbamazepine 💬 Carbamazepine [3] 6, 13, 231 💬
69 SCN3A 💬 [1] Taste transduction Lamotrigine 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬
70 SCN3A 💬 [1] Taste transduction Lidocaine 💬 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
71 SCN3A 💬 [1] Taste transduction Phenytoin 💬 Phenytoin [1] 13 💬
72 SCN3A 💬 [1] Taste transduction Oxcarbazepine 💬 Oxcarbazepine [1] 13 💬
73 SCN3A 💬 [1] Taste transduction Topiramate 💬 Topiramate [6] 6, 97, 140, 144, 156, 193 💬
74 SCN3A 💬 [1] Taste transduction Zonisamide 💬 Zonisamide [1] 6 💬
75 SCN3A 💬 [1] Taste transduction Amiodarone 💬 Amiodarone [2] 28, 127 💬
76 SCN3A 💬 [1] Taste transduction Cifenline 💬 Cibenzoline [1] 58 💬
77 SCN3A 💬 [1] Taste transduction Rufinamide 💬 Rufinamide [1] 144 💬
78 SCN3A 💬 [1] Taste transduction Lacosamide 💬 Lacosamide [4] 2, 46, 149, 298 💬
79 SCN3A 💬 [1] Taste transduction Bupivacaine 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
80 SCN3A 💬 [1] Taste transduction Flecainide 💬 Flecainide [1] 6 💬
81 SCN3A 💬 [1] Taste transduction Levobupivacaine 💬 Levobupivacaine [1] 46 💬
82 SCN3A 💬 [1] Taste transduction Lidocaine hydrochloride monohydrate 💬 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
83 SCN3A 💬 [1] Taste transduction Mexiletine 💬 Mexiletine [5] 1, 2, 10, 113, 114 💬
84 SCN3A 💬 [1] Taste transduction Oxybuprocaine 💬 Oxybuprocaine [1] 6 💬
85 SCN3A 💬 [1] Taste transduction Quinidine 💬 Quinidine [3] 2, 8, 13 💬
86 SCN3A 💬 [1] Taste transduction Ropivacaine 💬 Ropivacaine [4] 22, 36, 46, 70 💬
87 SCN3A 💬 [1] Taste transduction Eleclazine 💬 Eleclazine [1] 58 💬
88 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Carbamazepine 💬 Carbamazepine [3] 6, 13, 231 💬
89 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Lamotrigine 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬
90 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Lidocaine 💬 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
91 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Phenytoin 💬 Phenytoin [1] 13 💬
92 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Oxcarbazepine 💬 Oxcarbazepine [1] 13 💬
93 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Topiramate 💬 Topiramate [6] 6, 97, 140, 144, 156, 193 💬
94 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Zonisamide 💬 Zonisamide [1] 6 💬
95 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Amiodarone 💬 Amiodarone [2] 28, 127 💬
96 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Cifenline 💬 Cibenzoline [1] 58 💬
97 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Rufinamide 💬 Rufinamide [1] 144 💬
98 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Bupivacaine 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
99 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Flecainide 💬 Flecainide [1] 6 💬
100 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Levobupivacaine 💬 Levobupivacaine [1] 46 💬
101 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Lidocaine hydrochloride monohydrate 💬 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
102 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Mexiletine 💬 Mexiletine [5] 1, 2, 10, 113, 114 💬
103 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Oxybuprocaine 💬 Oxybuprocaine [1] 6 💬
104 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Quinidine 💬 Quinidine [3] 2, 8, 13 💬
105 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Ropivacaine 💬 Ropivacaine [4] 22, 36, 46, 70 💬
106 SCN5A 💬 [1] Adrenergic signaling in cardiomyocytes Eleclazine 💬 Eleclazine [1] 58 💬
107 SCN9A 💬 [1] Taste transduction Carbamazepine 💬 Carbamazepine [3] 6, 13, 231 💬
108 SCN9A 💬 [1] Taste transduction Lamotrigine 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬
109 SCN9A 💬 [1] Taste transduction Lidocaine 💬 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
110 SCN9A 💬 [1] Taste transduction Phenytoin 💬 Phenytoin [1] 13 💬
111 SCN9A 💬 [1] Taste transduction Oxcarbazepine 💬 Oxcarbazepine [1] 13 💬
112 SCN9A 💬 [1] Taste transduction Topiramate 💬 Topiramate [6] 6, 97, 140, 144, 156, 193 💬
113 SCN9A 💬 [1] Taste transduction Zonisamide 💬 Zonisamide [1] 6 💬
114 SCN9A 💬 [1] Taste transduction Amiodarone 💬 Amiodarone [2] 28, 127 💬
115 SCN9A 💬 [1] Taste transduction Cifenline 💬 Cibenzoline [1] 58 💬
116 SCN9A 💬 [1] Taste transduction Rufinamide 💬 Rufinamide [1] 144 💬
117 SCN9A 💬 [1] Taste transduction Lacosamide 💬 Lacosamide [4] 2, 46, 149, 298 💬
118 SCN9A 💬 [1] Taste transduction Bupivacaine 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
119 SCN9A 💬 [1] Taste transduction Flecainide 💬 Flecainide [1] 6 💬
120 SCN9A 💬 [1] Taste transduction Levobupivacaine 💬 Levobupivacaine [1] 46 💬
121 SCN9A 💬 [1] Taste transduction Lidocaine hydrochloride monohydrate 💬 Lidocaine [13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
122 SCN9A 💬 [1] Taste transduction Mexiletine 💬 Mexiletine [5] 1, 2, 10, 113, 114 💬
123 SCN9A 💬 [1] Taste transduction Oxybuprocaine 💬 Oxybuprocaine [1] 6 💬
124 SCN9A 💬 [1] Taste transduction Quinidine 💬 Quinidine [3] 2, 8, 13 💬
125 SCN9A 💬 [1] Taste transduction Ropivacaine 💬 Ropivacaine [4] 22, 36, 46, 70 💬
126 SCN9A 💬 [1] Taste transduction Eleclazine 💬 Eleclazine [1] 58 💬
127 SCNN1A 💬 [2] Taste transduction, Aldosterone-regulated sodium reabsorption Amiloride 💬 Amiloride [4] 13, 67, 225, 299 💬
128 SCNN1B 💬 [2] Taste transduction, Aldosterone-regulated sodium reabsorption Amiloride 💬 Amiloride [4] 13, 67, 225, 299 💬
129 SCNN1G 💬 [2] Taste transduction, Aldosterone-regulated sodium reabsorption Amiloride 💬 Amiloride [4] 13, 67, 225, 299 💬
130 SLC5A2 💬 - Dapagliflozin 💬 Dapagliflozin [7] 19, 49, 66, 67, 86, 88, 222 💬
131 SLC5A2 💬 - Empagliflozin 💬 Empagliflozin [6] 58, 65, 67, 72, 97, 257 💬
132 SLC6A1 💬 [2] Synaptic vesicle cycle, GABAergic synapse Gabapentin 💬 Gabapentin [5] 6, 13, 19, 70, 298 💬
133 SLC6A2 💬 [1] Synaptic vesicle cycle Amoxapine 💬 Amoxapine [1] 46 💬
134 SLC6A2 💬 [1] Synaptic vesicle cycle Methylphenidate 💬 Methylphenidate [7] 6, 13, 34, 84, 113, 179, 206 💬
135 SLC6A2 💬 [1] Synaptic vesicle cycle Phentermine 💬 Phentermine [1] 97 💬
136 SLC6A2 💬 [1] Synaptic vesicle cycle Amitriptyline 💬 Amitriptyline [4] 78, 97, 226, 299 💬
137 SLC6A2 💬 [1] Synaptic vesicle cycle Atomoxetine 💬 Atomoxetine [4] 6, 8, 13, 17 💬
138 SLC6A2 💬 [1] Synaptic vesicle cycle Bupropion 💬 Bupropion [5] 8, 18, 21, 96, 171 💬
139 SLC6A2 💬 [1] Synaptic vesicle cycle Desipramine 💬 Desipramine [2] 120, 156 💬
140 SLC6A2 💬 [1] Synaptic vesicle cycle Doxepin 💬 Doxepin [1] 6 💬
141 SLC6A2 💬 [1] Synaptic vesicle cycle Duloxetine 💬 Duloxetine [2] 6, 13 💬
142 SLC6A2 💬 [1] Synaptic vesicle cycle Lisdexamfetamine 💬 Lisdexamfetamine [1] 13 💬
143 SLC6A2 💬 [1] Synaptic vesicle cycle Milnacipran 💬 Milnacipran [2] 46, 49 💬
144 SLC6A2 💬 [1] Synaptic vesicle cycle Nortriptyline 💬 Nortriptyline [2] 6, 226 💬
145 SLC6A2 💬 [1] Synaptic vesicle cycle Venlafaxine 💬 Venlafaxine [3] 6, 13, 46 💬
146 SLC6A2 💬 [1] Synaptic vesicle cycle Ampreloxetine 💬 Ampreloxetine [2] 6, 17 💬
147 SLC6A3 💬 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Armodafinil 💬 Armodafinil [3] 6, 13, 84 💬
148 SLC6A3 💬 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Methylphenidate 💬 Methylphenidate [7] 6, 13, 34, 84, 113, 179, 206 💬
149 SLC6A3 💬 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Phentermine 💬 Phentermine [1] 97 💬
150 SLC6A3 💬 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Bupropion 💬 Bupropion [5] 8, 18, 21, 96, 171 💬
151 SLC6A3 💬 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Lisdexamfetamine 💬 Lisdexamfetamine [1] 13 💬
152 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Amoxapine 💬 Amoxapine [1] 46 💬
153 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Fluoxetine 💬 Fluoxetine [6] 13, 17, 78, 86, 179, 206 💬
154 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Sertraline 💬 Sertraline [2] 6, 206 💬
155 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Paroxetine 💬 Paroxetine [4] 6, 13, 46, 85 💬
156 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Phentermine 💬 Phentermine [1] 97 💬
157 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Amitriptyline 💬 Amitriptyline [4] 78, 97, 226, 299 💬
158 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Citalopram 💬 Citalopram [7] 6, 8, 13, 18, 46, 98, 127 💬
159 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Desipramine 💬 Desipramine [2] 120, 156 💬
160 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Doxepin 💬 Doxepin [1] 6 💬
161 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Duloxetine 💬 Duloxetine [2] 6, 13 💬
162 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Escitalopram 💬 Escitalopram [4] 2, 6, 13, 46 💬
163 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
164 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Milnacipran 💬 Milnacipran [2] 46, 49 💬
165 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Nortriptyline 💬 Nortriptyline [2] 6, 226 💬
166 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Trazodone 💬 Trazodone [1] 2 💬
167 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Venlafaxine 💬 Venlafaxine [3] 6, 13, 46 💬
168 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Vortioxetine 💬 Vortioxetine [1] 6 💬
169 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Ampreloxetine 💬 Ampreloxetine [2] 6, 17 💬
170 SLC10A1 💬 [2] Bile secretion, Hepatitis B Maralixibat 💬 Maralixibat [3] 296, 297, 338 💬
171 SLC10A2 💬 [1] Bile secretion Elobixibat 💬 Elobixibat [1] 6 💬
172 SLC10A2 💬 [1] Bile secretion Maralixibat 💬 Maralixibat [3] 296, 297, 338 💬
173 SLC10A2 💬 [1] Bile secretion Odevixibat 💬 Odevixibat [3] 296, 297, 338 💬
174 SLC12A2 💬 [3] Salivary secretion, Pancreatic secretion, Vibrio cholerae infection Bumetanide 💬 Bumetanide [2] 6, 158 💬
175 SLC12A2 💬 [3] Salivary secretion, Pancreatic secretion, Vibrio cholerae infection Furosemide 💬 Furosemide [2] 6, 86 💬
176 SLC12A3 💬 - Hydrochlorothiazide 💬 Hydrochlorothiazide [4] 13, 67, 225, 235 💬
177 SLC12A3 💬 - Indapamide 💬 Indapamide [1] 13 💬
178 SLC12A3 💬 - Chlorothiazide 💬 Chlorothiazide [1] 225 💬
179 SLC12A3 💬 - Bendroflumethiazide 💬 Bendroflumethiazide [1] 67 💬
180 SLC18A2 💬 [7] Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism Tetrabenazine 💬 Tetrabenazine [1] 8 💬
181 SLC18A2 💬 [7] Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism Valbenazine 💬 Valbenazine [1] 8 💬
182 SLC18A2 💬 [7] Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism Deutetrabenazine 💬 Deutetrabenazine [1] 8 💬
183 SMN1 💬 - Onasemnogene abeparvovec 💬 Onasemnogene abeparvovec [1] 3 💬
184 SMN2 💬 - Nusinersen 💬 Nusinersen [1] 3 💬
185 SMN2 💬 [1] Nucleocytoplasmic transport Risdiplam 💬 Risdiplam [1] 3 💬
186 SMN2 💬 - Branaplam 💬 Branaplam [2] 3, 8 💬
187 SMO 💬 [5] Hedgehog signaling pathway, Axon guidance, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma Vismodegib 💬 Vismodegib [1] 85 💬
188 SMO 💬 [5] Hedgehog signaling pathway, Axon guidance, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma Taladegib 💬 Taladegib [1] 85 💬
189 SMPD1 💬 [5] Sphingolipid metabolism, Metabolic pathways, Sphingolipid signaling pathway, Lysosome, Necroptosis Olipudase alfa 💬 Olipudase alfa [1] 19 💬
190 SNAP25 💬 [2] Synaptic vesicle cycle, Insulin secretion Botulinum toxin type A 💬 Botulinum toxin type A [14] 2, 5, 6, 7, 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬
191 SNAP25 💬 [2] Synaptic vesicle cycle, Insulin secretion Rimabotulinumtoxin B 💬 Botulinum toxin type B [4] 2, 6, 13, 51 💬
192 SNCA 💬 [3] Alzheimer disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases Prasinezumab 💬 Prasinezumab [1] 6 💬
193 SOD1 💬 [8] Peroxisome, Longevity regulating pathway - multiple species, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - reactive oxygen species Tofersen 💬 Tofersen [1] 2 💬
194 SRC 💬 [42] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Mitophagy - animal, Endocytosis, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Bacterial invasion of epithelial cells, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Bladder cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Bosutinib 💬 Bosutinib [2] 2, 67 💬
195 SRC 💬 [42] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Mitophagy - animal, Endocytosis, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Bacterial invasion of epithelial cells, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Bladder cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Dasatinib 💬 Dasatinib [2] 51, 85 💬
196 SRC 💬 [42] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Mitophagy - animal, Endocytosis, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Bacterial invasion of epithelial cells, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Bladder cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Dasatinib 💬 Dasatinib [2] 51, 85 💬
197 SRC 💬 [42] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Mitophagy - animal, Endocytosis, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Bacterial invasion of epithelial cells, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Bladder cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Saracatinib 💬 Saracatinib [3] 6, 89, 272 💬
198 SRD5A1 💬 [2] Steroid hormone biosynthesis, Metabolic pathways Dutasteride 💬 Dutasteride [2] 1, 2 💬
199 SRD5A2 💬 [3] Steroid hormone biosynthesis, Metabolic pathways, Prostate cancer Finasteride 💬 Finasteride [1] 6 💬
200 SRD5A2 💬 [3] Steroid hormone biosynthesis, Metabolic pathways, Prostate cancer Dutasteride 💬 Dutasteride [2] 1, 2 💬
201 SSTR1 💬 [3] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Somatostatin 💬 Somatostatin [2] 67, 78 💬
202 SSTR1 💬 [3] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Pasireotide 💬 Pasireotide [3] 67, 74, 75 💬
203 SSTR2 💬 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion Octreotide 💬 Octreotide [7] 67, 75, 84, 85, 89, 193, 227 💬
204 SSTR2 💬 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion Somatostatin 💬 Somatostatin [2] 67, 78 💬
205 SSTR2 💬 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion Pasireotide 💬 Pasireotide [3] 67, 74, 75 💬
206 SSTR3 💬 [2] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Somatostatin 💬 Somatostatin [2] 67, 78 💬
207 SSTR3 💬 [2] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Pasireotide 💬 Pasireotide [3] 67, 74, 75 💬
208 SSTR4 💬 [1] Neuroactive ligand-receptor interaction Somatostatin 💬 Somatostatin [2] 67, 78 💬
209 SSTR5 💬 [3] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Somatostatin 💬 Somatostatin [2] 67, 78 💬
210 SSTR5 💬 [3] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Pasireotide 💬 Pasireotide [3] 67, 74, 75 💬
211 SYK 💬 [17] NF-kappa B signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Osteoclast differentiation, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Viral carcinogenesis Fostamatinib 💬 Fostamatinib [4] 46, 49, 61, 66 💬
212 S1PR4 💬 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Amiselimod 💬 Amiselimod [1] 97 💬
213 S1PR4 💬 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Etrasimod 💬 Etrasimod [3] 96, 97, 98 💬
214 S1PR4 💬 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Ozanimod 💬 Ozanimod [3] 13, 96, 97 💬
215 S1PR2 💬 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Amiselimod 💬 Amiselimod [1] 97 💬
216 S1PR2 💬 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Etrasimod 💬 Etrasimod [3] 96, 97, 98 💬
217 S1PR2 💬 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Ozanimod 💬 Ozanimod [3] 13, 96, 97 💬
218 SV2B 💬 [1] ECM-receptor interaction Padsevonil 💬 Padsevonil [1] 149 💬
219 SV2A 💬 [1] ECM-receptor interaction Levetiracetam 💬 Levetiracetam [5] 2, 4, 6, 13, 307 💬
220 SV2A 💬 [1] ECM-receptor interaction Brivaracetam 💬 Brivaracetam [2] 149, 309 💬
221 SV2A 💬 [1] ECM-receptor interaction Padsevonil 💬 Padsevonil [1] 149 💬