Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Rap1 signaling pathway 💬
1件: ADORA2A 💬 D00528 💬 Caffeine 9件:  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
2 Rap1 signaling pathway 💬
1件: ADORA2A 💬 D01453 💬 Caffeine 9件:  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
3 Rap1 signaling pathway 💬
1件: ADORA2A 💬 D04641 💬 Istradefylline 1件:  6  💬
4 Rap1 signaling pathway 💬
1件: ADORA2A 💬 D09717 💬 Preladenant 1件:  6  💬
5 Rap1 signaling pathway 💬
1件: ADORA2A 💬 D05711 💬 Regadenoson 1件: 58 💬
6 Rap1 signaling pathway 💬
1件: ADORA2A 💬 D02017 💬 Theophylline 2件: 236, 299 💬
7 Rap1 signaling pathway 💬
1件: ADORA2A 💬 D10174 💬 Tozadenant 1件:  6  💬
8 Rap1 signaling pathway 💬
2件: ADORA2A, ADORA2B 💬 D00045 💬 Adenosine 3件: 13, 58, 65 💬
9 Rap1 signaling pathway 💬
2件: ADORA2A, ADORA2B 💬 D02769 💬 Adenosine phosphate 1件: 46 💬
10 Rap1 signaling pathway 💬
1件: ADORA2B 💬 D00227 💬 Aminophylline 1件: 63 💬
11 Rap1 signaling pathway 💬
1件: ADORA2B 💬 D05429 💬 Aminophylline 1件: 63 💬
12 Rap1 signaling pathway 💬
1件: ADORA2B 💬 D00371 💬 Theophylline 2件: 236, 299 💬
13 Rap1 signaling pathway 💬
1件: ADORA2B 💬 D01712 💬 Theophylline 2件: 236, 299 💬
14 Rap1 signaling pathway 💬
1件: ADORA2B 💬 D06103 💬 Theophylline 2件: 236, 299 💬
15 Rap1 signaling pathway 💬
1件: ADORA2B 💬 D06104 💬 Theophylline 2件: 236, 299 💬
16 Rap1 signaling pathway 💬
1件: BRAF 💬 D10064 💬 Dabrafenib 1件: 34 💬
17 Rap1 signaling pathway 💬
6件: BRAF, FLT4, KDR, KIT, PDGFRB, RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
18 Rap1 signaling pathway 💬
6件: BRAF, FLT4, KDR, KIT, PDGFRB, RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
19 Rap1 signaling pathway 💬
1件: CNR1 💬 D10915 💬 Cannabidiol 19件:  2 ,  6 ,  8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
20 Rap1 signaling pathway 💬
1件: CNR1 💬 D00306 💬 Dronabinol 8件:  2 ,  8 , 13, 36, 46, 96, 271, 298 💬
21 Rap1 signaling pathway 💬
1件: CNR1 💬 D05099 💬 Nabilone 2件:  6 , 13 💬
22 Rap1 signaling pathway 💬
1件: CNR1 💬 D05731 💬 Rimonabant 1件: 193 💬
23 Rap1 signaling pathway 💬
7件: CSF1, FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 D06402 💬 Sunitinib 2件: 28, 34 💬
24 Rap1 signaling pathway 💬
7件: CSF1, FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 D08552 💬 Sunitinib 2件: 28, 34 💬
25 Rap1 signaling pathway 💬
2件: CSF1R, KIT 💬 D11270 💬 Pexidartinib 1件: 34 💬
26 Rap1 signaling pathway 💬
1件: DRD2 💬 D02004 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
27 Rap1 signaling pathway 💬
1件: DRD2 💬 D07460 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
28 Rap1 signaling pathway 💬
1件: DRD2 💬 D01164 💬 Aripiprazole 2件:  6 , 206 💬
29 Rap1 signaling pathway 💬
1件: DRD2 💬 D00780 💬 Bromocriptine 2件:  6 , 74 💬
30 Rap1 signaling pathway 💬
1件: DRD2 💬 D03165 💬 Bromocriptine 2件:  6 , 74 💬
31 Rap1 signaling pathway 💬
1件: DRD2 💬 D00702 💬 Buspirone 3件:  6 , 51, 179 💬
32 Rap1 signaling pathway 💬
1件: DRD2 💬 D07593 💬 Buspirone 3件:  6 , 51, 179 💬
33 Rap1 signaling pathway 💬
1件: DRD2 💬 D00987 💬 Cabergoline 3件:  6 , 74, 75 💬
34 Rap1 signaling pathway 💬
1件: DRD2 💬 D09997 💬 Cariprazine 1件: 21 💬
35 Rap1 signaling pathway 💬
1件: DRD2 💬 D00270 💬 Chlorpromazine 1件: 254 💬
36 Rap1 signaling pathway 💬
1件: DRD2 💬 D00789 💬 Chlorpromazine 1件: 254 💬
37 Rap1 signaling pathway 💬
1件: DRD2 💬 D03274 💬 Chlorpromazine 1件: 254 💬
38 Rap1 signaling pathway 💬
1件: DRD2 💬 D04034 💬 Chlorpromazine 1件: 254 💬
39 Rap1 signaling pathway 💬
1件: DRD2 💬 D09886 💬 Dexpramipexole 1件:  2  💬
40 Rap1 signaling pathway 💬
1件: DRD2 💬 D01745 💬 Domperidone 5件:  6 , 13, 17, 51, 230 💬
41 Rap1 signaling pathway 💬
1件: DRD2 💬 D07868 💬 Domperidone 5件:  6 , 13, 17, 51, 230 💬
42 Rap1 signaling pathway 💬
1件: DRD2 💬 D00633 💬 Dopamine 4件:  6 ,  7 , 74, 299 💬
43 Rap1 signaling pathway 💬
1件: DRD2 💬 D07870 💬 Dopamine 4件:  6 ,  7 , 74, 299 💬
44 Rap1 signaling pathway 💬
1件: DRD2 💬 D01044 💬 Flupentixol 1件: 97 💬
45 Rap1 signaling pathway 💬
1件: DRD2 💬 D11839 💬 Foslevodopa 1件:  6  💬
46 Rap1 signaling pathway 💬
1件: DRD2 💬 D00136 💬 Haloperidol 1件:  8  💬
47 Rap1 signaling pathway 💬
1件: DRD2 💬 D01898 💬 Haloperidol 1件:  8  💬
48 Rap1 signaling pathway 💬
1件: DRD2 💬 D00059 💬 Levodopa 8件:  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
49 Rap1 signaling pathway 💬
1件: DRD2 💬 D01462 💬 Lisuride 2件:  6 , 86 💬
50 Rap1 signaling pathway 💬
1件: DRD2 💬 D08132 💬 Lisuride 2件:  6 , 86 💬
51 Rap1 signaling pathway 💬
1件: DRD2 💬 D07309 💬 Melperone 1件:  6  💬
52 Rap1 signaling pathway 💬
1件: DRD2 💬 D00726 💬 Metoclopramide 1件: 51 💬
53 Rap1 signaling pathway 💬
1件: DRD2 💬 D02213 💬 Metoclopramide 1件: 51 💬
54 Rap1 signaling pathway 💬
1件: DRD2 💬 D05008 💬 Metoclopramide 1件: 51 💬
55 Rap1 signaling pathway 💬
1件: DRD2 💬 D00454 💬 Olanzapine 2件:  2 ,  8  💬
56 Rap1 signaling pathway 💬
1件: DRD2 💬 D06623 💬 Olanzapine 2件:  2 ,  8  💬
57 Rap1 signaling pathway 💬
1件: DRD2 💬 D09397 💬 Pardoprunox 1件:  6  💬
58 Rap1 signaling pathway 💬
1件: DRD2 💬 D00502 💬 Pergolide 1件:  6  💬
59 Rap1 signaling pathway 💬
1件: DRD2 💬 D08339 💬 Pergolide 1件:  6  💬
60 Rap1 signaling pathway 💬
1件: DRD2 💬 D00560 💬 Pimozide 1件:  2  💬
61 Rap1 signaling pathway 💬
1件: DRD2 💬 D07305 💬 Piribedil 1件:  6  💬
62 Rap1 signaling pathway 💬
1件: DRD2 💬 D00559 💬 Pramipexole 3件:  2 ,  6 , 20 💬
63 Rap1 signaling pathway 💬
1件: DRD2 💬 D05575 💬 Pramipexole 3件:  2 ,  6 , 20 💬
64 Rap1 signaling pathway 💬
1件: DRD2 💬 D09953 💬 Pridopidine 3件:  2 ,  6 ,  8  💬
65 Rap1 signaling pathway 💬
1件: DRD2 💬 D00458 💬 Quetiapine 2件:  6 , 13 💬
66 Rap1 signaling pathway 💬
1件: DRD2 💬 D08456 💬 Quetiapine 2件:  6 , 13 💬
67 Rap1 signaling pathway 💬
1件: DRD2 💬 D00426 💬 Risperidone 5件:  8 , 156, 179, 187, 206 💬
68 Rap1 signaling pathway 💬
1件: DRD2 💬 D00784 💬 Ropinirole 4件:  2 ,  6 , 74, 309 💬
69 Rap1 signaling pathway 💬
1件: DRD2 💬 D08489 💬 Ropinirole 4件:  2 ,  6 , 74, 309 💬
70 Rap1 signaling pathway 💬
1件: DRD2 💬 D05768 💬 Rotigotine 2件:  6 , 127 💬
71 Rap1 signaling pathway 💬
1件: DRD2 💬 D01226 💬 Sulpiride 5件:  2 ,  6 , 17, 46, 70 💬
72 Rap1 signaling pathway 💬
1件: DRD2 💬 D08549 💬 Sulpiride 5件:  2 ,  6 , 17, 46, 70 💬
73 Rap1 signaling pathway 💬
1件: DRD2 💬 D01348 💬 Terguride 2件: 51, 86 💬
74 Rap1 signaling pathway 💬
1件: DRD2 💬 D08590 💬 Tiapride 1件:  8  💬
75 Rap1 signaling pathway 💬
1件: DRD2 💬 D00799 💬 Trifluoperazine 2件: 283, 284 💬
76 Rap1 signaling pathway 💬
1件: DRD2 💬 D01448 💬 Trifluoperazine 2件: 283, 284 💬
77 Rap1 signaling pathway 💬
1件: DRD2 💬 D08636 💬 Trifluoperazine 2件: 283, 284 💬
78 Rap1 signaling pathway 💬
1件: EGFR 💬 D03455 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
79 Rap1 signaling pathway 💬
1件: EGFR 💬 D04023 💬 Erlotinib 1件: 94 💬
80 Rap1 signaling pathway 💬
1件: EGFR 💬 D07907 💬 Erlotinib 1件: 94 💬
81 Rap1 signaling pathway 💬
1件: EGFR 💬 D01977 💬 Gefitinib 1件: 75 💬
82 Rap1 signaling pathway 💬
1件: EGFR 💬 D11251 💬 Icotinib 1件: 34 💬
83 Rap1 signaling pathway 💬
1件: EGFR 💬 D04024 💬 Lapatinib 3件: 34, 74, 75 💬
84 Rap1 signaling pathway 💬
1件: EGFR 💬 D08108 💬 Lapatinib 3件: 34, 74, 75 💬
85 Rap1 signaling pathway 💬
3件: EGFR, FLT4, KDR 💬 D11772 💬 Tesevatinib 1件: 67 💬
86 Rap1 signaling pathway 💬
4件: EPHA2, KIT, PDGFRB, SRC 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
87 Rap1 signaling pathway 💬
4件: EPHA2, KIT, PDGFRB, SRC 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
88 Rap1 signaling pathway 💬
1件: FGF23 💬 D10913 💬 Burosumab 1件: 238 💬
89 Rap1 signaling pathway 💬
3件: FGFR1, FGFR2, FGFR3 💬 D11589 💬 Infigratinib 1件: 276 💬
90 Rap1 signaling pathway 💬
8件: FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 D10481 💬 Nintedanib 5件: 51, 85, 89, 227, 228 💬
91 Rap1 signaling pathway 💬
1件: FGFR2 💬 D05338 💬 Palifermin 5件: 13, 36, 38, 39, 65 💬
92 Rap1 signaling pathway 💬
3件: FLT1, FLT4, KDR 💬 D03218 💬 Axitinib 1件: 34 💬
93 Rap1 signaling pathway 💬
3件: FLT1, FLT4, KDR 💬 D08881 💬 Cediranib 1件: 34 💬
94 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D02780 💬 Acamprosate 2件:  6 , 206 💬
95 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D07058 💬 Acamprosate 2件:  6 , 206 💬
96 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D00777 💬 Amantadine 4件:  6 ,  8 , 13, 127 💬
97 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D07441 💬 Amantadine 4件:  6 ,  8 , 13, 127 💬
98 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D00848 💬 Dextromethorphan 11件:  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
99 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D03742 💬 Dextromethorphan 11件:  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
100 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D03744 💬 Dextromethorphan 11件:  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
101 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D07283 💬 Esketamine 3件:  2 ,  4 , 70 💬
102 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D00711 💬 Ketamine 8件:  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
103 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D08098 💬 Ketamine 8件:  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
104 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D09917 💬 Latrepirdine 1件:  8  💬
105 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D04905 💬 Memantine 7件:  2 ,  6 ,  8 , 13, 49, 127, 205 💬
106 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D08174 💬 Memantine 7件:  2 ,  6 ,  8 , 13, 49, 127, 205 💬
107 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
108 Rap1 signaling pathway 💬
1件: IGF1R 💬 D09925 💬 Linsitinib 1件: 232 💬
109 Rap1 signaling pathway 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
110 Rap1 signaling pathway 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
111 Rap1 signaling pathway 💬
1件: IGF1R 💬 D09680 💬 Teprotumumab 1件: 51 💬
112 Rap1 signaling pathway 💬
1件: INSR 💬 D04539 💬 Insulin detemir 1件: 299 💬
113 Rap1 signaling pathway 💬
1件: INSR 💬 D03250 💬 Insulin glargine 1件: 299 💬
114 Rap1 signaling pathway 💬
1件: INSR 💬 D00085 💬 Insulin human 2件: 96, 156 💬
115 Rap1 signaling pathway 💬
1件: INSR 💬 D03230 💬 Insulin human 2件: 96, 156 💬
116 Rap1 signaling pathway 💬
1件: ITGAL 💬 D03959 💬 Efalizumab 9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 💬
117 Rap1 signaling pathway 💬
2件: KDR, MET 💬 D10062 💬 Cabozantinib 1件: 34 💬
118 Rap1 signaling pathway 💬
1件: KIT 💬 D10229 💬 Masitinib 6件:  2 ,  5 ,  6 , 13, 46, 96 💬
119 Rap1 signaling pathway 💬
2件: KIT, PDGFRA 💬 D01441 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
120 Rap1 signaling pathway 💬
2件: KIT, PDGFRA 💬 D08066 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
121 Rap1 signaling pathway 💬
3件: KIT, PDGFRA, PDGFRB 💬 D08953 💬 Nilotinib 5件:  6 ,  8 , 34, 51, 86 💬
122 Rap1 signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
123 Rap1 signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
124 Rap1 signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
125 Rap1 signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
126 Rap1 signaling pathway 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
127 Rap1 signaling pathway 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
128 Rap1 signaling pathway 💬
1件: NGF 💬 D09387 💬 Tanezumab 2件: 226, 298 💬
129 Rap1 signaling pathway 💬
1件: NGFR 💬 D11028 💬 Cenegermin 2件: 53, 90 💬
130 Rap1 signaling pathway 💬
3件: PGF, VEGFA, VEGFB 💬 D09574 💬 Aflibercept 2件: 90, 166 💬
131 Rap1 signaling pathway 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
132 Rap1 signaling pathway 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
133 Rap1 signaling pathway 💬
1件: SRC 💬 D03252 💬 Bosutinib 2件:  2 , 67 💬
134 Rap1 signaling pathway 💬
1件: SRC 💬 D09664 💬 Saracatinib 3件:  6 , 89, 272 💬
135 Rap1 signaling pathway 💬
1件: VEGFA 💬 D06409 💬 Bevacizumab 9件: 13, 34, 85, 86, 87, 89, 227, 280, 331 💬
136 Rap1 signaling pathway 💬
1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬