Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Adalimumab [7] ADALIMUMAB; AMGEVITA; Cyltezo; Hulio; HUMIRA; Hyrimoz; Imraldi[1] Adalimumab 💬[1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
2 Aloe vera leaf [3] Aloe; Aloe vera; Aloe vera gel---[2] 97, 226 💬
3 Amitriptyline [3] Amitriptylin; AMITRIPTYLINE; Amitriptyline hydrochloride[1] Amitriptyline 💬[2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[4] 78, 97, 226, 299 💬
4 AQX-1125 [1] AQX-1125---[1] 226 💬
5 Botulinum toxin type A [8] BOTOX; Botulinum toxin A; BOTULINUM TOXIN TYPE A; BTX-A; Dysport; IncobotulinumtoxinA; OnabotulinumtoxinA; Xeomin[1] Botulinum toxin type A 💬[1] SNAP25 💬[2] Insulin secretion, Synaptic vesicle cycle 💬[14] 2, 5, 6, 7, 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬
6 Buckwheat [1] Buckwheat---[1] 226 💬
7 Bupivacaine [2] Bupivacaine; BUPIVACAINE HYDROCHLORIDE[1] Bupivacaine 💬[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[8] 46, 51, 53, 70, 96, 168, 226, 298 💬
8 Cannabidiol [4] CANNABIDIOL; Epidiolex; Epidyolex; SATIVEX[1] Cannabidiol 💬[2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[20] 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
9 Capsaicin [2] Capsaicin; Qutenza[1] Capsaicin 💬[1] TRPV1 💬[2] Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[3] 6, 86, 226 💬
10 Certolizumab pegol [2] CERTOLIZUMAB PEGOL; CIMZIA[1] Certolizumab pegol 💬[1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[8] 37, 46, 49, 96, 97, 107, 226, 271 💬
11 Chondroitin sulfate [1] Chondroitin sulfate---[2] 96, 226 💬
12 Cyclosporine [10] CICLOSPORIN; CICLOSPORINA; Ciclosporine; Cyclosporin; Cyclosporin A; Cyclosporine; Cyclosporine A; Ikervis; Neoral; Restasis[1] Cyclosporine 💬[5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
13 Dexmedetomidine [4] Dexdor; DEXMEDETOMIDINA; DEXMEDETOMIDINE; DEXMEDETOMIDINE HYDROCHLORIDE[1] Dexmedetomidine 💬[3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[14] 2, 4, 6, 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
14 Dextrose, unspecified form [3] Dextrose; Glucose; Smofkabiven---[16] 2, 6, 13, 49, 50, 60, 65, 66, 70, 86, 88, 96, 97, 226, 257, 299 💬
15 Dimethyl sulfoxide [2] Dimethyl sulfoxide; DMSO[1] Dimethyl sulfoxide 💬--[1] 226 💬
16 Estradiol [1] Estradiol[1] Estradiol 💬[2] ESR1,
ESR2 💬		[10] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[7] 13, 46, 49, 65, 76, 226, 299 💬
17 Flavoxate [1] Flavoxate[1] Flavoxate 💬[16] PDE10A,
PDE11A,
PDE1A,
PDE1B,
PDE1C,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE7A,
PDE7B,
PDE8A,
PDE8B 💬		[18] Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Cortisol synthesis and secretion, Cushing syndrome, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Progesterone-mediated oocyte maturation, Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion, Taste transduction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 226 💬
18 Fospropofol [1] Fospropofol---[1] 226 💬
19 Fremanezumab [1] Fremanezumab[1] Fremanezumab 💬[1] CALCA 💬[2] Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction 💬[2] 124, 226 💬
20 Gefapixant [1] Gefapixant[1] Gefapixant 💬[1] P2RX3 💬[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Taste transduction 💬[2] 85, 226 💬
21 Glycine [1] GLYCINE[1] Glycine 💬--[5] 35, 60, 86, 226, 299 💬
22 Gold [1] Gold---[43] 2, 5, 6, 13, 17, 34, 35, 46, 49, 50, 53, 58, 63, 65, 68, 76, 84, 86, 91, 93, 95, 96, 97, 98, 113, 137, 158, 162, 167, 171, 193, 218, 222, 224, 226, 227, 230, 271, 291, 296, 298, 310, 318 💬
23 Heparin [2] Heparin; Heparin Sodium[1] Adomiparin 💬[1] SERPINC1 💬[1] Complement and coagulation cascades 💬[11] 47, 60, 70, 84, 107, 224, 226, 280, 299, 316, 317 💬
24 Hyaluronic acid [2] Hyaluronate; Hyaluronic acid[1] Hyaluronic acid 💬--[6] 46, 53, 70, 97, 226, 231 💬
25 Hydrogen [2] Dihydrogen; Hydrogen---[7] 5, 6, 17, 65, 83, 97, 226 💬
26 Ketorolac [2] Ketorolac; Ketorolac Tromethamine[1] Ketorolac 💬[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[2] 70, 226 💬
27 Lidocaine [4] Aloe; Lidocaine; Lignocaine; Xylocaine[2] Lidocaine ,
Lidocaine hydrochloride monohydrate 💬		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
28 Manganese citrate [1] Release---[12] 6, 8, 13, 46, 65, 78, 81, 96, 97, 206, 226, 299 💬
29 Metoprolol [2] Metoprolol; METOPROLOL SUCCINATE[1] Metoprolol 💬[1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 17, 57, 58, 113, 193, 226 💬
30 Mirabegron [1] Mirabegron[1] Mirabegron 💬[1] ADRB3 💬[8] Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cGMP-PKG signaling pathway 💬[4] 6, 13, 53, 226 💬
31 Monomethyl fumarate [2] Bafiertam; Monomethyl fumarate[1] Monomethyl fumarate 💬--[16] 13, 35, 40, 46, 49, 50, 51, 60, 65, 66, 107, 162, 222, 224, 226, 299 💬
32 Mycophenolate mofetil [3] CELLCEPT; Mycophenolate Mofetil; Mycophenolate mofetil TEVA[1] Mycophenolate mofetil 💬[2] IMPDH1,
IMPDH2 💬		[4] Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Purine metabolism 💬[34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
33 Mycophenolic acid [5] Acido Micofenolico; MICOFENOLICO ACIDO; Mycophenolate; Mycophenolic Acid; Myfortic[1] Mycophenolic acid 💬[2] IMPDH1,
IMPDH2 💬		[4] Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Purine metabolism 💬[36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬
34 Naloxone [2] Naloxone; NALOXONE HYDROCHLORIDE[1] Naloxone 💬[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[2] 6, 226 💬
35 Naltrexone [2] Naltrexone; Naltrexone Hydrochloride[1] Naltrexone 💬[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
36 Nortriptyline [2] Nortriptyline; Nortriptyline hydrochloride[1] Nortriptyline 💬[2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 226 💬
37 Omalizumab [2] Omalizumab; XOLAIR[1] Omalizumab 💬[1] FCER1A 💬[4] Asthma, Fc epsilon RI signaling pathway, Phospholipase D signaling pathway, Sphingolipid signaling pathway 💬[7] 46, 53, 65, 98, 162, 226, 299 💬
38 Oxycodone [2] Oxycodone; OXYCODONE HYDROCHLORIDE[1] Oxycodone 💬[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[5] 6, 13, 70, 226, 298 💬
39 Oxytocin [2] OXYTOCIN; Syntocinon[1] Oxytocin 💬[1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[7] 6, 72, 127, 168, 193, 206, 226 💬
40 Ozone [1] Ozone---[3] 49, 51, 226 💬
41 PD-0299685 [1] PD-0299685---[1] 226 💬
42 Pentosan polysulfate [1] Pentosan polysulfate---[3] 19, 26, 226 💬
43 Propiverine [1] Propiverine[1] Propiverine 💬[9] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[43] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Prion disease, Regulation of actin cytoskeleton, Renin secretion, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 226 💬
44 Sildenafil [6] Mysildecard; Revatio; SILDENAFIL; SILDENAFIL CITRATE; SILDENAFILO; Viagra[1] Sildenafil 💬[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
45 Sulfate ion [1] Sulfate---[27] 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 85, 86, 96, 111, 218, 222, 224, 226, 265, 296, 297, 299 💬
46 Tacrolimus [2] Prograf; Tacrolimus[2] Tacrolimus ,
Tacrolimus 💬		[5] PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		[33] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
47 Tanezumab [1] Tanezumab[1] Tanezumab 💬[1] NGF 💬[9] Apoptosis, Calcium signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Rap1 signaling pathway, Ras signaling pathway 💬[2] 226, 298 💬
48 Tramadol [2] Tramadol; Ultracet[1] Tramadol 💬[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[5] 46, 70, 78, 226, 271 💬
49 Triamcinolone [4] Kenalog; Naltrexone; Triamcinolone; Triamcinolone Acetonide[1] Triamcinolone 💬[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[11] 35, 46, 53, 56, 70, 90, 96, 107, 162, 226, 298 💬
50 Tromethamine [4] Tham; Tris; Trometamol; Tromethamine[1] Tromethamine 💬--[5] 51, 96, 97, 226, 299 💬
51 Water [8] AVONEX; ENBREL; Hiberix; Indocyanine green; OMNITROPE; Sterile Water for Injection; Water; WATER FOR INJECTION[1] Water 💬--[21] 2, 5, 6, 13, 17, 22, 35, 46, 53, 57, 63, 65, 67, 78, 84, 96, 97, 206, 226, 278, 299 💬