DDrare: Database of Drug Development for Rare Diseases

Target Gene/Pathway（薬物標的遺伝子／パスウェイリスト）

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219 / 286 pathways

No.	KEGG PATHWAY 💬 Info on mouse-over On map, Yellow: Drug target, Red: All disease-related	KEGG GENES 💬 Info on mouse-over	KEGG DRUG 💬 Info on mouse-over	DrugBank	指定難病告示番号 💬 Info on mouse-over
1	Acute myeloid leukemia 💬	1件: CSF2 💬	D11343 💬	Otilimab	1件: 46 💬
2	Acute myeloid leukemia 💬	1件: KIT 💬	D01441 💬	Imatinib	12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
3	Acute myeloid leukemia 💬	1件: KIT 💬	D08066 💬	Imatinib	12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
4	Acute myeloid leukemia 💬	1件: KIT 💬	D10229 💬	Masitinib	6件: 2, 5, 6, 13, 46, 96 💬
5	Acute myeloid leukemia 💬	1件: MTOR 💬	D00753 💬	Sirolimus	40件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
6	Acute myeloid leukemia 💬	1件: NFKB1 💬	D01146 💬	Iguratimod	4件: 46, 51, 53, 271 💬
7	Adipocytokine signaling pathway 💬	1件: JAK2 💬	D10308 💬	Baricitinib	9件: 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
8	Adipocytokine signaling pathway 💬	1件: JAK2 💬	D10653 💬	Peficitinib	1件: 46 💬
9	Adipocytokine signaling pathway 💬	1件: JAK2 💬	D09970 💬	Tofacitinib	12件: 11, 40, 46, 49, 50, 51, 53, 84, 96, 97, 107, 271 💬
10	Adipocytokine signaling pathway 💬	1件: MTOR 💬	D00753 💬	Sirolimus	40件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
11	Adipocytokine signaling pathway 💬	1件: NFKB1 💬	D01146 💬	Iguratimod	4件: 46, 51, 53, 271 💬
12	Adipocytokine signaling pathway 💬	2件: PRKAA1, PRKAA2 💬	D00944 💬	Metformin	21件: 2, 6, 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
13	Adipocytokine signaling pathway 💬	2件: PRKAA1, PRKAA2 💬	D04966 💬	Metformin	21件: 2, 6, 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
14	Adipocytokine signaling pathway 💬	1件: TNF 💬	D02597 💬	Adalimumab	16件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
15	Adipocytokine signaling pathway 💬	1件: TNF 💬	D03441 💬	Certolizumab pegol	6件: 37, 46, 96, 97, 226, 271 💬
16	Adipocytokine signaling pathway 💬	1件: TNF 💬	D00742 💬	Etanercept	15件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 💬
17	Adipocytokine signaling pathway 💬	1件: TNF 💬	D04358 💬	Golimumab	6件: 46, 56, 84, 96, 97, 271 💬
18	Adipocytokine signaling pathway 💬	1件: TNF 💬	D02598 💬	Infliximab	25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
19	Adipocytokine signaling pathway 💬	1件: TNF 💬	D09944 💬	Ozoralizumab	1件: 46 💬
20	Adipocytokine signaling pathway 💬	1件: TNF 💬	D05393 💬	Pegsunercept	1件: 46 💬
21	Adipocytokine signaling pathway 💬	1件: TNF 💬	D01583 💬	Pirfenidone	10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
22	Adrenergic signaling in cardiomyocytes 💬	5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬	D00095 💬	Epinephrine	2件: 46, 96 💬
23	Adrenergic signaling in cardiomyocytes 💬	5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬	D00996 💬	Epinephrine	2件: 46, 96 💬
24	Adrenergic signaling in cardiomyocytes 💬	5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬	D02149 💬	Epinephrine	2件: 46, 96 💬
25	Adrenergic signaling in cardiomyocytes 💬	1件: AGTR1 💬	D00357 💬	Losartan	18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
26	Adrenergic signaling in cardiomyocytes 💬	1件: AGTR1 💬	D08146 💬	Losartan	18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
27	Adrenergic signaling in cardiomyocytes 💬	2件: AGTR1, AGTR2 💬	D00150 💬	Angiotensin II	7件: 17, 19, 46, 66, 86, 222, 224 💬
28	Adrenergic signaling in cardiomyocytes 💬	2件: AGTR1, AGTR2 💬	D02014 💬	Angiotensin II	7件: 17, 19, 46, 66, 86, 222, 224 💬
29	Adrenergic signaling in cardiomyocytes 💬	4件: ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00298 💬	Digoxin	3件: 8, 46, 210 💬
30	Adrenergic signaling in cardiomyocytes 💬	4件: CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬	D02716 💬	Pregabalin	5件: 13, 36, 46, 70, 298 💬
31	Adrenergic signaling in cardiomyocytes 💬	1件: SCN5A 💬	D01450 💬	Bupivacaine	8件: 46, 51, 53, 70, 96, 168, 226, 298 💬
32	Adrenergic signaling in cardiomyocytes 💬	1件: SCN5A 💬	D07552 💬	Bupivacaine	8件: 46, 51, 53, 70, 96, 168, 226, 298 💬
33	Adrenergic signaling in cardiomyocytes 💬	1件: SCN5A 💬	D01287 💬	Levobupivacaine	1件: 46 💬
34	Adrenergic signaling in cardiomyocytes 💬	1件: SCN5A 💬	D08116 💬	Levobupivacaine	1件: 46 💬
35	Adrenergic signaling in cardiomyocytes 💬	1件: SCN5A 💬	D00358 💬	Lidocaine	12件: 6, 13, 34, 46, 51, 70, 84, 86, 168, 226, 231, 256 💬
36	Adrenergic signaling in cardiomyocytes 💬	1件: SCN5A 💬	D02086 💬	Lidocaine	12件: 6, 13, 34, 46, 51, 70, 84, 86, 168, 226, 231, 256 💬
37	Adrenergic signaling in cardiomyocytes 💬	1件: SCN5A 💬	D08127 💬	Lidocaine	12件: 6, 13, 34, 46, 51, 70, 84, 86, 168, 226, 231, 256 💬
38	Adrenergic signaling in cardiomyocytes 💬	1件: SCN5A 💬	D04048 💬	Ropivacaine	3件: 36, 46, 70 💬
39	Adrenergic signaling in cardiomyocytes 💬	1件: SCN5A 💬	D08490 💬	Ropivacaine	3件: 36, 46, 70 💬
40	African trypanosomiasis 💬	1件: IFNG 💬	D04242 💬	Fontolizumab	1件: 46 💬
41	African trypanosomiasis 💬	4件: IL10, IL1B, IL6, TNF 💬	D01583 💬	Pirfenidone	10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
42	African trypanosomiasis 💬	2件: IL12A, IL12B 💬	D09214 💬	Ustekinumab	15件: 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
43	African trypanosomiasis 💬	1件: IL1B 💬	D09315 💬	Canakinumab	10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
44	African trypanosomiasis 💬	1件: IL6 💬	D10080 💬	Sirukumab	2件: 41, 46 💬
45	African trypanosomiasis 💬	1件: TNF 💬	D02597 💬	Adalimumab	16件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
46	African trypanosomiasis 💬	1件: TNF 💬	D03441 💬	Certolizumab pegol	6件: 37, 46, 96, 97, 226, 271 💬
47	African trypanosomiasis 💬	1件: TNF 💬	D00742 💬	Etanercept	15件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 💬
48	African trypanosomiasis 💬	1件: TNF 💬	D04358 💬	Golimumab	6件: 46, 56, 84, 96, 97, 271 💬
49	African trypanosomiasis 💬	1件: TNF 💬	D02598 💬	Infliximab	25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
50	African trypanosomiasis 💬	1件: TNF 💬	D09944 💬	Ozoralizumab	1件: 46 💬
51	African trypanosomiasis 💬	1件: TNF 💬	D05393 💬	Pegsunercept	1件: 46 💬
52	AGE-RAGE signaling pathway in diabetic complications 💬	1件: AGTR1 💬	D00150 💬	Angiotensin II	7件: 17, 19, 46, 66, 86, 222, 224 💬
53	AGE-RAGE signaling pathway in diabetic complications 💬	1件: AGTR1 💬	D02014 💬	Angiotensin II	7件: 17, 19, 46, 66, 86, 222, 224 💬
54	AGE-RAGE signaling pathway in diabetic complications 💬	1件: AGTR1 💬	D00357 💬	Losartan	18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
55	AGE-RAGE signaling pathway in diabetic complications 💬	1件: AGTR1 💬	D08146 💬	Losartan	18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
56	AGE-RAGE signaling pathway in diabetic complications 💬	5件: CCL2, IL1A, IL1B, IL6, TNF 💬	D01583 💬	Pirfenidone	10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
57	AGE-RAGE signaling pathway in diabetic complications 💬	1件: IL1B 💬	D09315 💬	Canakinumab	10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
58	AGE-RAGE signaling pathway in diabetic complications 💬	1件: IL6 💬	D10080 💬	Sirukumab	2件: 41, 46 💬
59	AGE-RAGE signaling pathway in diabetic complications 💬	1件: JAK2 💬	D10308 💬	Baricitinib	9件: 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
60	AGE-RAGE signaling pathway in diabetic complications 💬	1件: JAK2 💬	D10653 💬	Peficitinib	1件: 46 💬
61	AGE-RAGE signaling pathway in diabetic complications 💬	1件: JAK2 💬	D09970 💬	Tofacitinib	12件: 11, 40, 46, 49, 50, 51, 53, 84, 96, 97, 107, 271 💬
62	AGE-RAGE signaling pathway in diabetic complications 💬	1件: NFKB1 💬	D01146 💬	Iguratimod	4件: 46, 51, 53, 271 💬
63	AGE-RAGE signaling pathway in diabetic complications 💬	1件: TNF 💬	D02597 💬	Adalimumab	16件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
64	AGE-RAGE signaling pathway in diabetic complications 💬	1件: TNF 💬	D03441 💬	Certolizumab pegol	6件: 37, 46, 96, 97, 226, 271 💬
65	AGE-RAGE signaling pathway in diabetic complications 💬	1件: TNF 💬	D00742 💬	Etanercept	15件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 💬
66	AGE-RAGE signaling pathway in diabetic complications 💬	1件: TNF 💬	D04358 💬	Golimumab	6件: 46, 56, 84, 96, 97, 271 💬
67	AGE-RAGE signaling pathway in diabetic complications 💬	1件: TNF 💬	D02598 💬	Infliximab	25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
68	AGE-RAGE signaling pathway in diabetic complications 💬	1件: TNF 💬	D09944 💬	Ozoralizumab	1件: 46 💬
69	AGE-RAGE signaling pathway in diabetic complications 💬	1件: TNF 💬	D05393 💬	Pegsunercept	1件: 46 💬
70	Alcoholism 💬	1件: ADORA2A 💬	D00528 💬	Caffeine	9件: 2, 6, 13, 21, 46, 78, 96, 97, 265 💬
71	Alcoholism 💬	1件: ADORA2A 💬	D01453 💬	Caffeine	9件: 2, 6, 13, 21, 46, 78, 96, 97, 265 💬
72	Alcoholism 💬	2件: ADORA2A, ADORA2B 💬	D02769 💬	Adenosine phosphate	1件: 46 💬
73	Alcoholism 💬	1件: DRD2 💬	D01226 💬	Sulpiride	5件: 2, 6, 17, 46, 70 💬
74	Alcoholism 💬	1件: DRD2 💬	D08549 💬	Sulpiride	5件: 2, 6, 17, 46, 70 💬
75	Alcoholism 💬	5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D00848 💬	Dextromethorphan	11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
76	Alcoholism 💬	5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D03742 💬	Dextromethorphan	11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
77	Alcoholism 💬	5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D03744 💬	Dextromethorphan	11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
78	Aldosterone synthesis and secretion 💬	1件: AGTR1 💬	D00150 💬	Angiotensin II	7件: 17, 19, 46, 66, 86, 222, 224 💬
79	Aldosterone synthesis and secretion 💬	1件: AGTR1 💬	D02014 💬	Angiotensin II	7件: 17, 19, 46, 66, 86, 222, 224 💬
80	Aldosterone synthesis and secretion 💬	1件: AGTR1 💬	D00357 💬	Losartan	18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
81	Aldosterone synthesis and secretion 💬	1件: AGTR1 💬	D08146 💬	Losartan	18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
82	Aldosterone synthesis and secretion 💬	4件: ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00298 💬	Digoxin	3件: 8, 46, 210 💬
83	Aldosterone synthesis and secretion 💬	1件: MC2R 💬	D00146 💬	Corticotropin	13件: 2, 13, 14, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 💬
84	Aldosterone synthesis and secretion 💬	1件: NPR1 💬	D04051 💬	Erythrityl tetranitrate	1件: 46 💬
85	Aldosterone synthesis and secretion 💬	1件: NPR1 💬	D05147 💬	Nesiritide	2件: 46, 58 💬
86	Aldosterone synthesis and secretion 💬	1件: PDE2A 💬	D00528 💬	Caffeine	9件: 2, 6, 13, 21, 46, 78, 96, 97, 265 💬
87	Aldosterone synthesis and secretion 💬	1件: PDE2A 💬	D01453 💬	Caffeine	9件: 2, 6, 13, 21, 46, 78, 96, 97, 265 💬
88	Aldosterone-regulated sodium reabsorption 💬	4件: ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00298 💬	Digoxin	3件: 8, 46, 210 💬
89	Allograft rejection 💬	2件: CD80, CD86 💬	D03203 💬	Abatacept	26件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
90	Allograft rejection 💬	2件: CD80, CD86 💬	D03222 💬	Belatacept	1件: 46 💬
91	Allograft rejection 💬	1件: IFNG 💬	D04242 💬	Fontolizumab	1件: 46 💬
92	Allograft rejection 💬	2件: IL10, TNF 💬	D01583 💬	Pirfenidone	10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
93	Allograft rejection 💬	2件: IL12A, IL12B 💬	D09214 💬	Ustekinumab	15件: 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
94	Allograft rejection 💬	1件: TNF 💬	D02597 💬	Adalimumab	16件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
95	Allograft rejection 💬	1件: TNF 💬	D03441 💬	Certolizumab pegol	6件: 37, 46, 96, 97, 226, 271 💬
96	Allograft rejection 💬	1件: TNF 💬	D00742 💬	Etanercept	15件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 💬
97	Allograft rejection 💬	1件: TNF 💬	D04358 💬	Golimumab	6件: 46, 56, 84, 96, 97, 271 💬
98	Allograft rejection 💬	1件: TNF 💬	D02598 💬	Infliximab	25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
99	Allograft rejection 💬	1件: TNF 💬	D09944 💬	Ozoralizumab	1件: 46 💬
100	Allograft rejection 💬	1件: TNF 💬	D05393 💬	Pegsunercept	1件: 46 💬
101	Alzheimer disease 💬	1件: ADAM17 💬	D08859 💬	Apratastat	1件: 46 💬
102	Alzheimer disease 💬	5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D00848 💬	Dextromethorphan	11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
103	Alzheimer disease 💬	5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D03742 💬	Dextromethorphan	11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
104	Alzheimer disease 💬	5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D03744 💬	Dextromethorphan	11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
105	Alzheimer disease 💬	4件: IL1A, IL1B, IL6, TNF 💬	D01583 💬	Pirfenidone	10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
106	Alzheimer disease 💬	1件: IL1B 💬	D09315 💬	Canakinumab	10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
107	Alzheimer disease 💬	1件: IL6 💬	D10080 💬	Sirukumab	2件: 41, 46 💬
108	Alzheimer disease 💬	1件: MTOR 💬	D00753 💬	Sirolimus	40件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
109	Alzheimer disease 💬	1件: NFKB1 💬	D01146 💬	Iguratimod	4件: 46, 51, 53, 271 💬
110	Alzheimer disease 💬	5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00184 💬	Cyclosporine	43件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
111	Alzheimer disease 💬	5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	32件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
112	Alzheimer disease 💬	5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	32件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
113	Alzheimer disease 💬	1件: PSMB5 💬	D03150 💬	Bortezomib	15件: 11, 13, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 283, 288, 331 💬
114	Alzheimer disease 💬	1件: PTGS2 💬	D01545 💬	Aceclofenac	1件: 46 💬
115	Alzheimer disease 💬	1件: PTGS2 💬	D00217 💬	Acetaminophen	16件: 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271 💬
116	Alzheimer disease 💬	1件: PTGS2 💬	D00109 💬	Acetylsalicylic acid	14件: 13, 22, 34, 46, 49, 51, 86, 96, 97, 113, 158, 210, 231, 251 💬
117	Alzheimer disease 💬	1件: PTGS2 💬	D00567 💬	Celecoxib	9件: 2, 3, 34, 46, 70, 89, 161, 171, 271 💬
118	Alzheimer disease 💬	1件: PTGS2 💬	D00903 💬	Diclofenac	4件: 13, 34, 46, 271 💬
119	Alzheimer disease 💬	1件: PTGS2 💬	D00904 💬	Diclofenac	4件: 13, 34, 46, 271 💬
120	Alzheimer disease 💬	1件: PTGS2 💬	D07816 💬	Diclofenac	4件: 13, 34, 46, 271 💬
121	Alzheimer disease 💬	1件: PTGS2 💬	D00315 💬	Etodolac	1件: 46 💬
122	Alzheimer disease 💬	1件: PTGS2 💬	D03710 💬	Etoricoxib	2件: 46, 271 💬
123	Alzheimer disease 💬	1件: PTGS2 💬	D00330 💬	Flurbiprofen	3件: 13, 21, 46 💬
124	Alzheimer disease 💬	1件: PTGS2 💬	D01475 💬	Flurbiprofen	3件: 13, 21, 46 💬
125	Alzheimer disease 💬	1件: PTGS2 💬	D02290 💬	Flurbiprofen	3件: 13, 21, 46 💬
126	Alzheimer disease 💬	1件: PTGS2 💬	D00126 💬	Ibuprofen	6件: 13, 46, 65, 113, 271, 299 💬
127	Alzheimer disease 💬	1件: PTGS2 💬	D01122 💬	Ibuprofen	6件: 13, 46, 65, 113, 271, 299 💬
128	Alzheimer disease 💬	1件: PTGS2 💬	D04490 💬	Ibuprofen	6件: 13, 46, 65, 113, 271, 299 💬
129	Alzheimer disease 💬	1件: PTGS2 💬	D06606 💬	Ibuprofen	6件: 13, 46, 65, 113, 271, 299 💬
130	Alzheimer disease 💬	1件: PTGS2 💬	D00132 💬	Ketoprofen	1件: 46 💬
131	Alzheimer disease 💬	1件: PTGS2 💬	D08149 💬	Loxoprofen	2件: 46, 271 💬
132	Alzheimer disease 💬	1件: PTGS2 💬	D03714 💬	Lumiracoxib	1件: 46 💬
133	Alzheimer disease 💬	1件: PTGS2 💬	D00969 💬	Meloxicam	4件: 46, 49, 271, 296 💬
134	Alzheimer disease 💬	1件: PTGS2 💬	D00118 💬	Naproxen	3件: 13, 46, 271 💬
135	Alzheimer disease 💬	1件: PTGS2 💬	D01049 💬	Nimesulide	1件: 46 💬
136	Alzheimer disease 💬	1件: PTGS2 💬	D03716 💬	Parecoxib	2件: 46, 271 💬
137	Alzheimer disease 💬	1件: PTGS2 💬	D00568 💬	Rofecoxib	1件: 46 💬
138	Alzheimer disease 💬	1件: PTGS2 💬	D02709 💬	Valdecoxib	1件: 46 💬
139	Alzheimer disease 💬	1件: TNF 💬	D02597 💬	Adalimumab	16件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
140	Alzheimer disease 💬	1件: TNF 💬	D03441 💬	Certolizumab pegol	6件: 37, 46, 96, 97, 226, 271 💬
141	Alzheimer disease 💬	1件: TNF 💬	D00742 💬	Etanercept	15件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 💬
142	Alzheimer disease 💬	1件: TNF 💬	D04358 💬	Golimumab	6件: 46, 56, 84, 96, 97, 271 💬
143	Alzheimer disease 💬	1件: TNF 💬	D02598 💬	Infliximab	25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
144	Alzheimer disease 💬	1件: TNF 💬	D09944 💬	Ozoralizumab	1件: 46 💬
145	Alzheimer disease 💬	1件: TNF 💬	D05393 💬	Pegsunercept	1件: 46 💬
146	Alzheimer disease 💬	9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬	D00570 💬	Colchicine	7件: 2, 42, 46, 56, 93, 210, 266 💬
147	Alzheimer disease 💬	9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬	D00491 💬	Paclitaxel	2件: 46, 85 💬
148	Alzheimer disease 💬	9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬	D05333 💬	Paclitaxel	2件: 46, 85 💬
149	Amoebiasis 💬	1件: CSF2 💬	D11343 💬	Otilimab	1件: 46 💬
150	Amoebiasis 💬	1件: IFNG 💬	D04242 💬	Fontolizumab	1件: 46 💬
151	Amoebiasis 💬	4件: IL10, IL1B, IL6, TNF 💬	D01583 💬	Pirfenidone	10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
152	Amoebiasis 💬	2件: IL12A, IL12B 💬	D09214 💬	Ustekinumab	15件: 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
153	Amoebiasis 💬	1件: IL1B 💬	D09315 💬	Canakinumab	10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
154	Amoebiasis 💬	2件: IL1R1, IL1R2 💬	D02934 💬	Anakinra	19件: 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
155	Amoebiasis 💬	1件: IL6 💬	D10080 💬	Sirukumab	2件: 41, 46 💬
156	Amoebiasis 💬	1件: NFKB1 💬	D01146 💬	Iguratimod	4件: 46, 51, 53, 271 💬
157	Amoebiasis 💬	1件: TNF 💬	D02597 💬	Adalimumab	16件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
158	Amoebiasis 💬	1件: TNF 💬	D03441 💬	Certolizumab pegol	6件: 37, 46, 96, 97, 226, 271 💬
159	Amoebiasis 💬	1件: TNF 💬	D00742 💬	Etanercept	15件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 💬
160	Amoebiasis 💬	1件: TNF 💬	D04358 💬	Golimumab	6件: 46, 56, 84, 96, 97, 271 💬
161	Amoebiasis 💬	1件: TNF 💬	D02598 💬	Infliximab	25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
162	Amoebiasis 💬	1件: TNF 💬	D09944 💬	Ozoralizumab	1件: 46 💬
163	Amoebiasis 💬	1件: TNF 💬	D05393 💬	Pegsunercept	1件: 46 💬
164	Amphetamine addiction 💬	5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D00848 💬	Dextromethorphan	11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
165	Amphetamine addiction 💬	5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D03742 💬	Dextromethorphan	11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
166	Amphetamine addiction 💬	5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	D03744 💬	Dextromethorphan	11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
167	Amphetamine addiction 💬	5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00184 💬	Cyclosporine	43件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
168	Amphetamine addiction 💬	5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	32件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
169	Amphetamine addiction 💬	5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	32件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
170	AMPK signaling pathway 💬	1件: ADRA1A 💬	D00095 💬	Epinephrine	2件: 46, 96 💬
171	AMPK signaling pathway 💬	1件: ADRA1A 💬	D00996 💬	Epinephrine	2件: 46, 96 💬
172	AMPK signaling pathway 💬	1件: ADRA1A 💬	D02149 💬	Epinephrine	2件: 46, 96 💬
173	AMPK signaling pathway 💬	1件: HMGCR 💬	D00887 💬	Atorvastatin	17件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
174	AMPK signaling pathway 💬	1件: HMGCR 💬	D07474 💬	Atorvastatin	17件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
175	AMPK signaling pathway 💬	1件: HMGCR 💬	D00359 💬	Lovastatin	11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
176	AMPK signaling pathway 💬	1件: HMGCR 💬	D00893 💬	Pravastatin	9件: 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
177	AMPK signaling pathway 💬	1件: HMGCR 💬	D08410 💬	Pravastatin	9件: 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
178	AMPK signaling pathway 💬	1件: HMGCR 💬	D01915 💬	Rosuvastatin	11件: 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
179	AMPK signaling pathway 💬	1件: HMGCR 💬	D08492 💬	Rosuvastatin	11件: 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
180	AMPK signaling pathway 💬	1件: HMGCR 💬	D00434 💬	Simvastatin	21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
181	AMPK signaling pathway 💬	1件: MTOR 💬	D00753 💬	Sirolimus	40件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
182	AMPK signaling pathway 💬	1件: PPARG 💬	D00945 💬	Pioglitazone	17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
183	AMPK signaling pathway 💬	1件: PPARG 💬	D08378 💬	Pioglitazone	17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
184	AMPK signaling pathway 💬	1件: PPARG 💬	D00596 💬	Rosiglitazone	5件: 46, 75, 97, 222, 265 💬
185	AMPK signaling pathway 💬	1件: PPARG 💬	D08491 💬	Rosiglitazone	5件: 46, 75, 97, 222, 265 💬
186	AMPK signaling pathway 💬	2件: PRKAA1, PRKAA2 💬	D00944 💬	Metformin	21件: 2, 6, 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
187	AMPK signaling pathway 💬	2件: PRKAA1, PRKAA2 💬	D04966 💬	Metformin	21件: 2, 6, 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
188	Amyotrophic lateral sclerosis 💬	6件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬	D00848 💬	Dextromethorphan	11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
189	Amyotrophic lateral sclerosis 💬	6件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬	D03742 💬	Dextromethorphan	11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
190	Amyotrophic lateral sclerosis 💬	6件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬	D03744 💬	Dextromethorphan	11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
191	Amyotrophic lateral sclerosis 💬	1件: MTOR 💬	D00753 💬	Sirolimus	40件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
192	Amyotrophic lateral sclerosis 💬	5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00184 💬	Cyclosporine	43件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
193	Amyotrophic lateral sclerosis 💬	5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	32件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
194	Amyotrophic lateral sclerosis 💬	5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	32件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
195	Amyotrophic lateral sclerosis 💬	1件: PSMB5 💬	D03150 💬	Bortezomib	15件: 11, 13, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 283, 288, 331 💬
196	Amyotrophic lateral sclerosis 💬	1件: TNF 💬	D02597 💬	Adalimumab	16件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
197	Amyotrophic lateral sclerosis 💬	1件: TNF 💬	D03441 💬	Certolizumab pegol	6件: 37, 46, 96, 97, 226, 271 💬
198	Amyotrophic lateral sclerosis 💬	1件: TNF 💬	D00742 💬	Etanercept	15件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 💬
199	Amyotrophic lateral sclerosis 💬	1件: TNF 💬	D04358 💬	Golimumab	6件: 46, 56, 84, 96, 97, 271 💬
200	Amyotrophic lateral sclerosis 💬	1件: TNF 💬	D02598 💬	Infliximab	25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
201	Amyotrophic lateral sclerosis 💬	1件: TNF 💬	D09944 💬	Ozoralizumab	1件: 46 💬
202	Amyotrophic lateral sclerosis 💬	1件: TNF 💬	D05393 💬	Pegsunercept	1件: 46 💬
203	Amyotrophic lateral sclerosis 💬	1件: TNF 💬	D01583 💬	Pirfenidone	10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
204	Amyotrophic lateral sclerosis 💬	9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬	D00570 💬	Colchicine	7件: 2, 42, 46, 56, 93, 210, 266 💬
205	Amyotrophic lateral sclerosis 💬	9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬	D00491 💬	Paclitaxel	2件: 46, 85 💬
206	Amyotrophic lateral sclerosis 💬	9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬	D05333 💬	Paclitaxel	2件: 46, 85 💬
207	Antifolate resistance 💬	2件: DHFR, DHFR2 💬	D00142 💬	Methotrexate	35件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
208	Antifolate resistance 💬	2件: DHFR, DHFR2 💬	D02115 💬	Methotrexate	35件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
209	Antifolate resistance 💬	1件: IL1B 💬	D09315 💬	Canakinumab	10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
210	Antifolate resistance 💬	3件: IL1B, IL6, TNF 💬	D01583 💬	Pirfenidone	10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
211	Antifolate resistance 💬	1件: IL6 💬	D10080 💬	Sirukumab	2件: 41, 46 💬
212	Antifolate resistance 💬	1件: NFKB1 💬	D01146 💬	Iguratimod	4件: 46, 51, 53, 271 💬
213	Antifolate resistance 💬	1件: TNF 💬	D02597 💬	Adalimumab	16件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
214	Antifolate resistance 💬	1件: TNF 💬	D03441 💬	Certolizumab pegol	6件: 37, 46, 96, 97, 226, 271 💬
215	Antifolate resistance 💬	1件: TNF 💬	D00742 💬	Etanercept	15件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 228, 271, 285, 298 💬
216	Antifolate resistance 💬	1件: TNF 💬	D04358 💬	Golimumab	6件: 46, 56, 84, 96, 97, 271 💬
217	Antifolate resistance 💬	1件: TNF 💬	D02598 💬	Infliximab	25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56,