Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 2,2-bis(4-hydroxy-3-tert-butylphenyl)propane [0] ---[5] 19, 86, 90, 276, 299 💬
2 Acetamide [1] Acetamide---[2] 86, 154 💬
3 Acetaminophen [4] Acetaminophen; PARACETAMOL; Tylenol; Ultracet[1] Acetaminophen 💬[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[15] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬
4 Acetate [1] Acetate---[41] 1, 2, 6, 10, 13, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 171, 206, 222, 224, 225, 227, 235, 251, 265, 288, 298, 299 💬
5 Acetazolamide [1] Acetazolamide[1] Acetazolamide 💬[13] CA1,
CA12,
CA13,
CA14,
CA2,
CA3,
CA4,
CA5A,
CA5B,
CA6,
CA7,
CA8,
CA9 💬		[7] Bile secretion, Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Nitrogen metabolism, Pancreatic secretion, Proximal tubule bicarbonate reclamation 💬[8] 13, 86, 90, 115, 154, 155, 225, 230 💬
6 Acetic acid C-11 [1] 11C-ACETATE---[4] 6, 13, 86, 88 💬
7 Acetylsalicylic acid [2] Acetylsalicylic acid; Aspirin[1] Aspirin 💬[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬
8 Activated charcoal [1] Carbon---[6] 6, 85, 86, 96, 97, 158 💬
9 Albendazole [2] Albendazole; Eskazole[1] Albendazole 💬--[12] 5, 6, 7, 13, 28, 51, 67, 86, 96, 97, 114, 127 💬
10 Alunacedase alfa [1] Recombinant Human Angiotensin-Converting Enzyme 2---[1] 86 💬
11 Ambrisentan [3] AMBRISENTAN; Letairis; Volibris[1] Ambrisentan 💬[1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[7] 51, 84, 85, 86, 88, 210, 211 💬
12 Aminohippuric acid [1] Aminohippurate[1] Aminohippuric acid 💬--[4] 49, 53, 67, 86 💬
13 Anakinra [2] Anakinra; Kineret[1] Anakinra 💬[2] IL1R1,
IL1R2 💬		[15] Amoebiasis, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[18] 2, 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
14 Anastrozole [2] ANASTROZOLE; Arimidex[1] Anastrozole 💬[1] CYP19A1 💬[3] Metabolic pathways, Ovarian steroidogenesis, Steroid hormone biosynthesis 💬[3] 78, 86, 193 💬
15 Angiotensin II [2] Angiotensin; Angiotensin II[2] Angiotensin II ,
Angiotensin II 💬		[2] AGTR1,
AGTR2 💬		[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[7] 17, 19, 46, 66, 86, 222, 224 💬
16 Apabetalone [1] Apabetalone[1] Apabetalone 💬[4] BRD2,
BRD3,
BRD4,
BRDT 💬		-[1] 86 💬
17 Aspartame [0] [1] Aspartame 💬[2] TAS1R2,
TAS1R3 💬		[2] Carbohydrate digestion and absorption, Taste transduction 💬[4] 6, 13, 67, 86 💬
18 AV-101 [1] AV-101---[2] 6, 86 💬
19 Aviptadil [1] Aviptadil[1] Aviptadil 💬--[5] 49, 51, 84, 85, 86 💬
20 Bardoxolone [1] Bardoxolone[1] Bardoxolone 💬--[7] 66, 67, 84, 85, 86, 218, 222 💬
21 Bardoxolone methyl [1] Bardoxolone methyl[1] Bardoxolone methyl 💬--[7] 66, 67, 84, 85, 86, 218, 222 💬
22 Benzbromarone [1] BENZBROMARONE[1] Benzbromarone 💬[1] SLC22A12 💬-[1] 86 💬
23 Beraprost [1] Beraprost[1] Beraprost 💬[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86 💬
24 BIA [1] BIA---[2] 6, 86 💬
25 Bisoprolol [2] Bisoprolol; Bisoprolol Fumarate[1] Bisoprolol 💬[1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 58, 67, 86, 113 💬
26 Bosentan [2] BOSENTAN; TRACLEER[2] Bosentan ,
Bosentan 💬		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
27 Capsaicin [2] Capsaicin; Qutenza[1] Capsaicin 💬[1] TRPV1 💬[2] Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[3] 6, 86, 226 💬
28 Captopril [1] Captopril[1] Captopril 💬[1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[8] 6, 17, 46, 86, 96, 97, 107, 271 💬
29 Carbon monoxide [1] Carbon monoxide[1] Carbon monoxide 💬--[4] 13, 53, 85, 86 💬
30 Carvedilol [1] CARVEDILOL[1] Carvedilol 💬[5] ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
ADRB2 💬		[13] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 57, 86, 113, 210 💬
31 Cetuximab [2] Cetuximab; Erbitux[1] Cetuximab 💬[1] EGFR 💬[48] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis 💬[2] 51, 86 💬
32 Chlorhexidine [2] Chlorhexidine; Chlorhexidine Gluconate[1] Chlorhexidine 💬--[2] 86, 299 💬
33 Cicletanine [1] Cicletanine[1] Cicletanine 💬--[1] 86 💬
34 Citrulline [1] Citrulline---[2] 86, 113 💬
35 Clopidogrel [1] Clopidogrel[3] Clopidogrel ,
Clopidogrel hydrochloride ,
Clopidogrel besilate 💬		[1] P2RY12 💬[1] Platelet activation 💬[3] 49, 51, 86 💬
36 Conivaptan [1] Conivaptan[1] Conivaptan 💬[2] AVPR1A,
AVPR2 💬		[5] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Vasopressin-regulated water reabsorption 💬[1] 86 💬
37 CXA-10 [1] CXA-10---[2] 86, 222 💬
38 D-glucose [2] D-glucose; Glucose[1] Glucose 💬--[3] 49, 86, 88 💬
39 Dapagliflozin [2] Dapagliflozin; Forxiga[1] Dapagliflozin 💬[1] SLC5A2 💬-[7] 19, 49, 66, 67, 86, 88, 222 💬
40 Dextrose, unspecified form [3] Dextrose; Glucose; Smofkabiven---[16] 2, 6, 13, 49, 50, 60, 65, 66, 70, 86, 88, 96, 97, 226, 257, 299 💬
41 Dichloroacetic acid [1] Dichloroacetate---[1] 86 💬
42 Diltiazem [2] Diltiazem; Diltiazem Hydrochloride[1] Diltiazem 💬[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 51, 58, 86 💬
43 Dimethyl fumarate [3] Dimethyl fumarate; Dimethylfumarat; TECFIDERA[1] Dimethyl fumarate 💬[1] KEAP1 💬[6] Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬[5] 13, 49, 51, 86, 296 💬
44 Diphenhydramine [2] Diphenhydramine; Diphenhydramine hydrochloride[1] Diphenhydramine 💬[1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[8] 11, 13, 49, 51, 70, 86, 222, 256 💬
45 Dobutamine [2] Dobutamin; Dobutamine[1] Dobutamine 💬[1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 57, 58, 86, 215 💬
46 Elafin [1] Elafin---[1] 86 💬
47 Epicatechin [1] Epicatechin---[2] 86, 113 💬
48 Epoprostenol [6] EPOPROSTENOL; Epoprostenol for injection; EPOPROSTENOL SODIUM; Flolan; Prostacyclin; Veletri[1] Epoprostenol 💬[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86 💬
49 Esomeprazole [3] Esomeprazole; Nexium; Omeprazole[1] Esomeprazole 💬[2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[8] 13, 46, 86, 98, 107, 113, 298, 299 💬
50 Famotidine [2] FAMOTIDINA; Famotidine[1] Famotidine 💬[1] HRH2 💬[3] Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction 💬[6] 6, 46, 61, 86, 98, 107 💬
51 Ferric carboxymaltose [1] Ferric carboxymaltose[1] Ferric carboxymaltose 💬--[4] 86, 96, 97, 299 💬
52 Fluoxetine [5] Fluoxetin; FLUOXETINE; FLUOXETINE HYDROCHLORIDE; Fluoxétine; PROZAC[1] Fluoxetine 💬[1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[6] 13, 17, 78, 86, 179, 206 💬
53 Fulvestrant [2] Faslodex; Fulvestrant[1] Fulvestrant 💬[2] ESR1,
ESR2 💬		[10] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[2] 49, 86 💬
54 Furosemide [2] Furosemide; Furosemide Injection[1] Furosemide 💬[1] SLC12A2 💬[3] Pancreatic secretion, Salivary secretion, Vibrio cholerae infection 💬[2] 6, 86 💬
55 Gadobenic acid [2] Gadobenate; MultiHance[1] Gadobenic acid 💬--[3] 13, 86, 88 💬
56 Glycine [1] Glycine[1] Glycine 💬--[5] 35, 60, 86, 226, 299 💬
57 Gold [1] Gold---[43] 2, 5, 6, 13, 17, 34, 35, 46, 49, 50, 53, 58, 63, 65, 68, 76, 84, 86, 91, 93, 95, 96, 97, 98, 113, 137, 158, 162, 167, 171, 193, 218, 222, 224, 226, 227, 230, 271, 291, 296, 298, 310, 318 💬
58 GSK2256098 [1] GSK2256098---[1] 86 💬
59 Hydroxyurea [1] Hydroxyurea[1] Hydroxyurea 💬[1] RRM2 💬[7] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Nucleotide metabolism, Purine metabolism, Pyrimidine metabolism, p53 signaling pathway 💬[8] 3, 13, 19, 20, 65, 85, 86, 284 💬
60 Iloprost [2] Iloprost; Ventavis[1] Iloprost 💬[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[4] 51, 84, 85, 86 💬
61 Imatinib [4] Gleevec; GLIVEC; Imatinib; Imatinib Mesylate[1] Imatinib 💬[3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
62 Ipratropium [1] Ipratropium---[2] 6, 86 💬
63 Iron Dextran [1] Iron Dextran[1] Iron dextran 💬--[4] 62, 86, 96, 97 💬
64 Iron polymaltose [1] Fusion---[9] 11, 13, 46, 49, 69, 70, 86, 271, 299 💬
65 Levocarnitine [4] Carnitine; L-Carnitine; Levocarnitine; Xyzal[1] Levocarnitine 💬--[11] 3, 5, 13, 53, 58, 86, 96, 97, 265, 298, 316 💬
66 Lidocaine [4] Aloe; Lidocaine; Lignocaine; Xylocaine[2] Lidocaine ,
Lidocaine hydrochloride monohydrate 💬		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
67 Lisuride [1] LISURIDE[1] Lisuride 💬[3] DRD2,
DRD3,
DRD4 💬		[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 6, 86 💬
68 Macitentan [2] MACITENTAN; Opsumit[1] Macitentan 💬[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 51, 85, 86, 88, 210 💬
69 Medical air [1] Medical air---[4] 85, 86, 97, 193 💬
70 Metformin [5] Metformin; Metformin HCl; Metformin hydrochloride; Metformina; Metformine[1] Metformin 💬[2] PRKAA1,
PRKAA2 💬		[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬[25] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
71 Methylprednisolone [4] Medrol; Methylprednisolon; Methylprednisolone; METHYLPREDNISOLONE ACETATE[1] Methylprednisolone 💬[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[46] 2, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
72 Morphine [2] Morphine; Morphine Sulfate[1] Morphine 💬[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[5] 36, 46, 70, 85, 86 💬
73 Moxifloxacin [2] Moxifloxacin; Moxifloxacin Hydrochloride[1] Moxifloxacin 💬--[9] 2, 6, 46, 49, 85, 86, 113, 240, 299 💬
74 Nicardipine [1] Nicardipine[1] Nicardipine 💬[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 70, 86 💬
75 Nilotinib [2] Nilotinib; TASIGNA[1] Nilotinib 💬[4] ABL1,
KIT,
PDGFRA,
PDGFRB 💬		[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[5] 6, 8, 34, 51, 86 💬
76 Nitric Oxide [3] INOmax; NITRIC OXIDE; Nitrosyl[1] Nitric oxide 💬--[12] 6, 58, 85, 86, 88, 97, 210, 222, 251, 294, 299, 321 💬
77 Nitrite [1] Nitrite---[2] 58, 86 💬
78 Olaparib [1] Olaparib[1] Olaparib 💬[2] PARP1,
PARP2 💬		[5] Apoptosis, Base excision repair, Diabetic cardiomyopathy, NF-kappa B signaling pathway, Necroptosis 💬[2] 86, 285 💬
79 Oxygen [3] Medical air; Nitrogen; OXYGEN[1] Oxygen 💬--[13] 6, 49, 70, 85, 86, 88, 90, 96, 168, 193, 271, 299, 330 💬
80 Pentoxifylline [1] Pentoxifylline[1] Pentoxifylline 💬--[12] 26, 56, 84, 86, 93, 96, 97, 113, 220, 222, 296, 298 💬
81 PF-00489791 [1] PF-00489791---[1] 86 💬
82 Pioglitazone [1] Pioglitazone[1] Pioglitazone 💬[1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
83 Placental Mesenchymal Stem Cells [2] Placental Mesenchymal Stem Cells; PLX-PAD---[2] 86, 118 💬
84 Prasterone [3] Dehydroepiandrosterone; DHEA; Prasterone[1] Prasterone 💬[3] AR,
ESR1,
ESR2 💬		[12] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Oocyte meiosis, Pathways in cancer, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[6] 49, 53, 83, 86, 96, 113 💬
85 Prednisone [3] Prednisona; Prednisone; RAYOS[1] Prednisone 💬[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[45] 2, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331 💬
86 Ralinepag [1] RALINEPAG[1] Ralinepag 💬[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[1] 86 💬
87 Ranolazine [3] RANEXA; Ranolazina; Ranolazine[1] Ranolazine 💬--[6] 2, 58, 86, 96, 113, 114 💬
88 Rifampicin [2] Rifampicin; Rifampin[1] Rifampin 💬--[9] 6, 13, 17, 46, 84, 86, 93, 299, 338 💬
89 Riociguat [2] Adempas; RIOCIGUAT[1] Riociguat 💬[3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[6] 51, 84, 86, 88, 225, 299 💬
90 Ritonavir [2] Norvir; Ritonavir[1] Ritonavir 💬--[3] 2, 86, 265 💬
91 Rituximab [6] MABTHERA; Rituxan; Rituximab; Rixathon; Ruxience; TRUXIMA[1] Rituximab 💬[1] MS4A1 💬[1] Hematopoietic cell lineage 💬[48] 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
92 Salbutamol [3] Albuterol; Salbutamol; Ventolin[1] Albuterol 💬[1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[12] 3, 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬
93 Sapropterin [5] 6R-BH4; KUVAN; Sapropterin; SAPROPTERIN DIHYDROCHLORIDE; Tetrahydrobiopterin[1] Sapropterin 💬--[5] 51, 86, 124, 240, 299 💬
94 Saquinavir [1] Saquinavir[1] Saquinavir 💬--[2] 86, 265 💬
95 Satralizumab [3] Enspryng; Sapelizumab; SATRALIZUMAB[1] Satralizumab 💬[1] IL6R 💬[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[3] 11, 13, 86 💬
96 Selexipag [2] SELEXIPAG; Uptravi[1] Selexipag 💬[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[5] 51, 70, 84, 86, 88 💬
97 Selonsertib [1] Selonsertib[1] Selonsertib 💬[1] MAP3K5 💬[20] Alcoholic liver disease, Alzheimer disease, Amyotrophic lateral sclerosis, Apoptosis, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Huntington disease, Lipid and atherosclerosis, MAPK signaling pathway, Neurotrophin signaling pathway, Non-alcoholic fatty liver disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Platinum drug resistance, Protein processing in endoplasmic reticulum, Sphingolipid signaling pathway, Spinocerebellar ataxia, TNF signaling pathway, Thermogenesis, Tight junction 💬[1] 86 💬
98 Serine [2] L-Serine; Serine[1] Serine 💬--[4] 2, 6, 86, 96 💬
99 Sildenafil [6] Mysildecard; Revatio; SILDENAFIL; Sildenafil Citrate; SILDENAFILO; Viagra[1] Sildenafil 💬[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
100 Simvastatin [3] Simvastatin; Simvastatina; Simvastatine[1] Simvastatin 💬[1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
101 Sirolimus [3] RAPAMUNE; Rapamycin; Sirolimus[1] Sirolimus 💬[1] MTOR 💬[51] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬[40] 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
102 Sitaxentan [3] Sitaxentan; Sitaxsentan; Thelin[1] Sitaxentan 💬[1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 86 💬
103 Sodium dichloroacetate [1] Dichloroacetate Sodium[1] Sodium dichloroacetate 💬[3] PDK2,
PDK3,
PDK4 💬		[1] Diabetic cardiomyopathy 💬[1] 86 💬
104 Sorafenib [2] Nexavar; Sorafenib[1] Sorafenib 💬[8] BRAF,
FLT3,
FLT4,
KDR,
KIT,
PDGFRB,
RAF1,
RET 💬		[89] Acute myeloid leukemia, Alcoholism, Alzheimer disease, Apelin signaling pathway, Apoptosis, Autophagy - animal, Axon guidance, B cell receptor signaling pathway, Bladder cancer, Breast cancer, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Chronic myeloid leukemia, Colorectal cancer, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endometrial cancer, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Influenza A, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Renal cell carcinoma, Salmonella infection, Serotonergic synapse, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, Thyroid cancer, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Tuberculosis, VEGF signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[2] 34, 86 💬
105 Sotatercept [1] Sotatercept[1] Sotatercept 💬[1] ACVR2A 💬[4] Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway 💬[2] 86, 284 💬
106 Spironolactone [1] Spironolactone[1] Spironolactone 💬[1] NR3C2 💬[1] Aldosterone-regulated sodium reabsorption 💬[8] 46, 58, 67, 86, 113, 210, 218, 225 💬
107 Sulfasalazine [3] Salazosulfapyridine; Salicylazosulfapyridine; Sulfasalazine[1] Sulfasalazine 💬--[6] 46, 86, 94, 107, 270, 271 💬
108 Sulfate ion [1] Sulfate---[27] 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 85, 86, 96, 111, 218, 222, 224, 226, 265, 296, 297, 299 💬
109 Tadalafil [4] Adcirca; Cialis; Tadalafil; TADALAFILO[1] Tadalafil 💬[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[7] 6, 51, 75, 84, 86, 113, 210 💬
110 Terguride [1] Terguride[1] Terguride 💬[2] DRD2,
PRL 💬		[12] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬[2] 51, 86 💬
111 Tezosentan [1] Tezosentan---[1] 86 💬
112 Threonine [1] Threonine[1] Threonine 💬--[2] 86, 97 💬
113 Tocilizumab [3] ACTEMRA; ROACTEMRA; Tocilizumab[1] Tocilizumab 💬[1] IL6R 💬[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[21] 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
114 Tolvaptan [3] Jinarc; Samsca; Tolvaptan[1] Tolvaptan 💬[1] AVPR2 💬[3] Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬[4] 67, 72, 86, 225 💬
115 Treprostinil [4] Remodulin; Treprostinil; Treprostinilo; Tyvaso[1] Treprostinil 💬[1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[6] 51, 84, 85, 86, 88, 210 💬
116 Trimetazidine [1] Trimetazidine[1] Trimetazidine 💬--[3] 2, 58, 86 💬
117 Tyrosine [4] Alanine; L-Tyrosine; Propanoic acid; Tyrosine[1] Tyrosine 💬--[5] 6, 75, 86, 111, 298 💬
118 Ubenimex [1] Ubenimex[1] Ubenimex 💬[1] ANPEP 💬[4] Glutathione metabolism, Hematopoietic cell lineage, Metabolic pathways, Renin-angiotensin system 💬[1] 86 💬
119 Ubidecarenone [3] Coenzyme Q-10; Coenzyme Q10; CoQ10[1] Ubidecarenone 💬--[12] 2, 5, 6, 8, 10, 18, 46, 57, 86, 113, 214, 215 💬
120 Udenafil [1] Udenafil[1] Udenafil 💬[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[2] 86, 210 💬
121 Ularitide [1] ULARITIDE---[1] 86 💬
122 Vardenafil [3] Levitra; Vardenafil; Vardenafilo[1] Vardenafil 💬[1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[3] 13, 86, 299 💬
123 Warfarin [2] Warfarin; Warfarin Sodium[1] Warfarin 💬[2] NQO1,
VKORC1 💬		[7] Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬[11] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
124 Zamicastat [1] ZAMICASTAT---[1] 86 💬