Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 SIGMAR1 💬 2件: Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
2 ADORA1 💬 7件: cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
3 ADORA1 💬 7件: cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
4 ADORA2A 💬 7件: Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Parkinson disease, Alcoholism Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
5 ADORA2A 💬 7件: Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Parkinson disease, Alcoholism Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
6 ADRA2A 💬 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction Clonidine 💬 Clonidine 4件: 6, 65, 70, 78 💬
7 ADRA2B 💬 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction Clonidine 💬 Clonidine 4件: 6, 65, 70, 78 💬
8 ADRA2C 💬 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction Clonidine 💬 Clonidine 4件: 6, 65, 70, 78 💬
9 CYP19A1 💬 3件: Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis Anastrozole 💬 Anastrozole 3件: 78, 86, 193 💬
10 GHR 💬 5件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action Mecasermin 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
11 GHR 💬 5件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action Pegvisomant 💬 Pegvisomant 2件: 78, 265 💬
12 GHR 💬 5件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action Somavaratan 💬 Somavaratan 1件: 78 💬
13 GHR 💬 5件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action Somapacitan 💬 Somapacitan 2件: 78, 195 💬
14 GHR 💬 5件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action Lonapegsomatropin 💬 Lonapegsomatropin 1件: 78 💬
15 GHRHR 💬 2件: Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Tesamorelin 💬 Tesamorelin 2件: 78, 265 💬
16 GHRHR 💬 2件: Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Somatorelin 💬 Somatorelin 2件: 13, 78 💬
17 GHSR 💬 3件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Macimorelin 💬 Macimorelin 1件: 78 💬
18 GLP1R 💬 3件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Insulin secretion Exenatide 💬 Exenatide 6件: 6, 17, 72, 78, 193, 233 💬
19 GRIN1 💬 18件: Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
20 GRIN2A 💬 19件: Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
21 GRIN2B 💬 19件: Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
22 GRIN2C 💬 15件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
23 GRIN2D 💬 15件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
24 NR3C1 💬 1件: Neuroactive ligand-receptor interaction Hydrocortisone 💬 Hydrocortisone 10件: 6, 41, 46, 53, 75, 78, 81, 83, 97, 299 💬
25 IGF1R 💬 29件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Oocyte meiosis, Autophagy - animal, Endocytosis, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Focal adhesion, Adherens junction, Signaling pathways regulating pluripotency of stem cells, Long-term depression, Ovarian steroidogenesis, Progesterone-mediated oocyte maturation, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Glioma, Prostate cancer, Melanoma, Breast cancer, Hepatocellular carcinoma Mecasermin 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
26 AR 💬 4件: Oocyte meiosis, Pathways in cancer, Chemical carcinogenesis - receptor activation, Prostate cancer Testosterone 💬 Testosterone 8件: 1, 2, 3, 13, 60, 76, 78, 113 💬
27 MC2R 💬 5件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome Cosyntropin 💬 Tetracosactide 5件: 78, 83, 113, 145, 222 💬
28 ACHE 💬 2件: Glycerophospholipid metabolism, Cholinergic synapse Donepezil 💬 Donepezil 9件: 5, 6, 13, 46, 78, 124, 127, 156, 206 💬
29 MTNR1A 💬 2件: Neuroactive ligand-receptor interaction, Circadian entrainment Melatonin 💬 Melatonin 12件: 6, 8, 13, 37, 46, 49, 72, 78, 90, 97, 145, 202 💬
30 MTNR1B 💬 2件: Neuroactive ligand-receptor interaction, Circadian entrainment Melatonin 💬 Melatonin 12件: 6, 8, 13, 37, 46, 49, 72, 78, 90, 97, 145, 202 💬
31 OPRM1 💬 3件: Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction Tramadol 💬 Tramadol 5件: 46, 70, 78, 226, 271 💬
32 PDE2A 💬 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, Olfactory transduction, Aldosterone synthesis and secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
33 PDE2A 💬 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, Olfactory transduction, Aldosterone synthesis and secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
34 PDE3A 💬 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
35 PDE3A 💬 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
36 PDE3B 💬 11件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
37 PDE3B 💬 11件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
38 PDE4A 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
39 PDE4A 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
40 PDE4B 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
41 PDE4B 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
42 PDE4C 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
43 PDE4C 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
44 PDE4D 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
45 PDE4D 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
46 PDE1B 💬 7件: Purine metabolism, Metabolic pathways, Calcium signaling pathway, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
47 PDE1B 💬 7件: Purine metabolism, Metabolic pathways, Calcium signaling pathway, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
48 PPARG 💬 11件: PPAR signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Pioglitazone 💬 Pioglitazone 17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
49 PTGS1 💬 5件: Arachidonic acid metabolism, Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes Diclofenac 💬 Diclofenac 5件: 13, 34, 46, 78, 271 💬
50 PTGS2 💬 22件: Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer Diclofenac 💬 Diclofenac 5件: 13, 34, 46, 78, 271 💬
51 SLC6A2 💬 1件: Synaptic vesicle cycle Amitriptyline 💬 Amitriptyline 4件: 78, 97, 226, 299 💬
52 SLC6A4 💬 2件: Synaptic vesicle cycle, Serotonergic synapse Fluoxetine 💬 Fluoxetine 6件: 13, 17, 78, 86, 179, 206 💬
53 SLC6A4 💬 2件: Synaptic vesicle cycle, Serotonergic synapse Amitriptyline 💬 Amitriptyline 4件: 78, 97, 226, 299 💬
54 SSTR1 💬 3件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Somatostatin 💬 Somatostatin 2件: 67, 78 💬
55 SSTR2 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion Somatostatin 💬 Somatostatin 2件: 67, 78 💬
56 SSTR3 💬 2件: Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Somatostatin 💬 Somatostatin 2件: 67, 78 💬
57 SSTR4 💬 1件: Neuroactive ligand-receptor interaction Somatostatin 💬 Somatostatin 2件: 67, 78 💬
58 SSTR5 💬 3件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Somatostatin 💬 Somatostatin 2件: 67, 78 💬
59 THRA 💬 2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway Tiratricol 💬 Tiratricol 2件: 78, 139 💬
60 THRA 💬 2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway Levothyroxine 💬 Levothyroxine 5件: 19, 49, 78, 80, 222 💬
61 THRA 💬 2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway Liothyronine 💬 Liothyronine 4件: 13, 78, 210, 212 💬
62 THRB 💬 2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway Tiratricol 💬 Tiratricol 2件: 78, 139 💬
63 THRB 💬 2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway Levothyroxine 💬 Levothyroxine 5件: 19, 49, 78, 80, 222 💬
64 THRB 💬 2件: Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway Liothyronine 💬 Liothyronine 4件: 13, 78, 210, 212 💬
65 PDE5A 💬 3件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
66 PDE5A 💬 3件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬