Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 TUBB3 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D02197 Vincristine 4件: 26, 34, 65, 331
2 TUBB3 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D08679 Vincristine 4件: 26, 34, 65, 331
3 TUBB4A 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D02197 Vincristine 4件: 26, 34, 65, 331
4 TUBB4A 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D08679 Vincristine 4件: 26, 34, 65, 331
5 TUBB4B 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D02197 Vincristine 4件: 26, 34, 65, 331
6 TUBB4B 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D08679 Vincristine 4件: 26, 34, 65, 331
7 CSF3R 5件: Cytokine-cytokine receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬 D03235 Filgrastim 34件: 2, 6, 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331
8 DHFR 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
9 DHFR 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
10 ABAT 7件: Alanine, aspartate and glutamate metabolism 💬, Valine, leucine and isoleucine degradation 💬, beta-Alanine metabolism 💬, Propanoate metabolism 💬, Butanoate metabolism 💬, Metabolic pathways 💬, GABAergic synapse 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
11 EGFR 48件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Phospholipase D signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Gap junction 💬, JAK-STAT signaling pathway 💬, Regulation of actin cytoskeleton 💬, GnRH signaling pathway 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Cushing syndrome 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Shigellosis 💬, Hepatitis C 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D03455 Cetuximab 5件: 34, 51, 86, 89, 331
12 DHFR2 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
13 DHFR2 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
14 TUBB 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D02197 Vincristine 4件: 26, 34, 65, 331
15 TUBB 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D08679 Vincristine 4件: 26, 34, 65, 331
16 MTOR 51件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, ErbB signaling pathway 💬, HIF-1 signaling pathway 💬, Phospholipase D signaling pathway 💬, Autophagy - other 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Cellular senescence 💬, Apelin signaling pathway 💬, Neutrophil extracellular trap formation 💬, JAK-STAT signaling pathway 💬, Th17 cell differentiation 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Shigellosis 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Glioma 💬, Prostate cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Diabetic cardiomyopathy 💬 D00753 Sirolimus 41件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331
17 MTOR 51件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, ErbB signaling pathway 💬, HIF-1 signaling pathway 💬, Phospholipase D signaling pathway 💬, Autophagy - other 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Cellular senescence 💬, Apelin signaling pathway 💬, Neutrophil extracellular trap formation 💬, JAK-STAT signaling pathway 💬, Th17 cell differentiation 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Shigellosis 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Glioma 💬, Prostate cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Diabetic cardiomyopathy 💬 D06068 Temsirolimus 4件: 13, 34, 89, 331
18 GAD1 7件: Alanine, aspartate and glutamate metabolism 💬, beta-Alanine metabolism 💬, Taurine and hypotaurine metabolism 💬, Butanoate metabolism 💬, Metabolic pathways 💬, GABAergic synapse 💬, Type I diabetes mellitus 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
19 GAD2 7件: Alanine, aspartate and glutamate metabolism 💬, beta-Alanine metabolism 💬, Taurine and hypotaurine metabolism 💬, Butanoate metabolism 💬, Metabolic pathways 💬, GABAergic synapse 💬, Type I diabetes mellitus 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
20 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00473 Prednisone 1件: 331
21 TUBB8 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D02197 Vincristine 4件: 26, 34, 65, 331
22 TUBB8 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D08679 Vincristine 4件: 26, 34, 65, 331
23 TUBB2B 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D02197 Vincristine 4件: 26, 34, 65, 331
24 TUBB2B 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D08679 Vincristine 4件: 26, 34, 65, 331
25 IL6 51件: EGFR tyrosine kinase inhibitor resistance 💬, Antifolate resistance 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, PI3K-Akt signaling pathway 💬, Cellular senescence 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, IL-17 signaling pathway 💬, Th17 cell differentiation 💬, TNF signaling pathway 💬, Intestinal immune network for IgA production 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Hypertrophic cardiomyopathy 💬, Lipid and atherosclerosis 💬 D08976 Pomalidomide 6件: 28, 34, 51, 85, 227, 331
26 IL6 51件: EGFR tyrosine kinase inhibitor resistance 💬, Antifolate resistance 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, PI3K-Akt signaling pathway 💬, Cellular senescence 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, IL-17 signaling pathway 💬, Th17 cell differentiation 💬, TNF signaling pathway 💬, Intestinal immune network for IgA production 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Hypertrophic cardiomyopathy 💬, Lipid and atherosclerosis 💬 D09669 Siltuximab 2件: 28, 331
27 IL6R 12件: EGFR tyrosine kinase inhibitor resistance 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Th17 cell differentiation 💬, Non-alcoholic fatty liver disease 💬, Human cytomegalovirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬 D02596 Tocilizumab 21件: 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331
28 PSMB5 8件: Proteasome 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D03150 Bortezomib 16件: 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 228, 256, 283, 288, 331
29 BTK 7件: NF-kappa B signaling pathway 💬, Osteoclast differentiation 💬, Platelet activation 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Epstein-Barr virus infection 💬, Primary immunodeficiency 💬 D11422 Zanubrutinib 2件: 300, 331
30 TNF 67件: Antifolate resistance 💬, MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, NF-kappa B signaling pathway 💬, Sphingolipid signaling pathway 💬, mTOR signaling pathway 💬, Apoptosis 💬, Necroptosis 💬, TGF-beta signaling pathway 💬, Osteoclast differentiation 💬, Antigen processing and presentation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, C-type lectin receptor signaling pathway 💬, Hematopoietic cell lineage 💬, Natural killer cell mediated cytotoxicity 💬, IL-17 signaling pathway 💬, T cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, TNF signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Toxoplasmosis 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Proteoglycans in cancer 💬, Asthma 💬, Inflammatory bowel disease 💬, Systemic lupus erythematosus 💬, Rheumatoid arthritis 💬, Allograft rejection 💬, Graft-versus-host disease 💬, Hypertrophic cardiomyopathy 💬, Dilated cardiomyopathy 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D00754 Thalidomide 20件: 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
31 TNF 67件: Antifolate resistance 💬, MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, NF-kappa B signaling pathway 💬, Sphingolipid signaling pathway 💬, mTOR signaling pathway 💬, Apoptosis 💬, Necroptosis 💬, TGF-beta signaling pathway 💬, Osteoclast differentiation 💬, Antigen processing and presentation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, C-type lectin receptor signaling pathway 💬, Hematopoietic cell lineage 💬, Natural killer cell mediated cytotoxicity 💬, IL-17 signaling pathway 💬, T cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, TNF signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Toxoplasmosis 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Proteoglycans in cancer 💬, Asthma 💬, Inflammatory bowel disease 💬, Systemic lupus erythematosus 💬, Rheumatoid arthritis 💬, Allograft rejection 💬, Graft-versus-host disease 💬, Hypertrophic cardiomyopathy 💬, Dilated cardiomyopathy 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D04687 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331
32 TNF 67件: Antifolate resistance 💬, MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, NF-kappa B signaling pathway 💬, Sphingolipid signaling pathway 💬, mTOR signaling pathway 💬, Apoptosis 💬, Necroptosis 💬, TGF-beta signaling pathway 💬, Osteoclast differentiation 💬, Antigen processing and presentation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, C-type lectin receptor signaling pathway 💬, Hematopoietic cell lineage 💬, Natural killer cell mediated cytotoxicity 💬, IL-17 signaling pathway 💬, T cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, TNF signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Toxoplasmosis 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Proteoglycans in cancer 💬, Asthma 💬, Inflammatory bowel disease 💬, Systemic lupus erythematosus 💬, Rheumatoid arthritis 💬, Allograft rejection 💬, Graft-versus-host disease 💬, Hypertrophic cardiomyopathy 💬, Dilated cardiomyopathy 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D08976 Pomalidomide 6件: 28, 34, 51, 85, 227, 331
33 TOP2A 1件: Platinum drug resistance 💬 D00125 Etoposide 1件: 331
34 TOP2A 1件: Platinum drug resistance 💬 D03899 Doxorubicin 1件: 331
35 TOP2A 1件: Platinum drug resistance 💬 D04107 Etoposide 1件: 331
36 TOP2B 1件: Platinum drug resistance 💬 D00125 Etoposide 1件: 331
37 TOP2B 1件: Platinum drug resistance 💬 D03899 Doxorubicin 1件: 331
38 TOP2B 1件: Platinum drug resistance 💬 D04107 Etoposide 1件: 331
39 TUBB2A 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D02197 Vincristine 4件: 26, 34, 65, 331
40 TUBB2A 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D08679 Vincristine 4件: 26, 34, 65, 331
41 VEGFA 24件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Relaxin signaling pathway 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Bladder cancer 💬, Rheumatoid arthritis 💬, Fluid shear stress and atherosclerosis 💬 D06409 Bevacizumab 9件: 13, 34, 85, 86, 87, 89, 227, 280, 331
42 ALDH5A1 3件: Alanine, aspartate and glutamate metabolism 💬, Butanoate metabolism 💬, Metabolic pathways 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
43 TUBB1 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D02197 Vincristine 4件: 26, 34, 65, 331
44 TUBB1 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D08679 Vincristine 4件: 26, 34, 65, 331
45 TUBB6 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D02197 Vincristine 4件: 26, 34, 65, 331
46 TUBB6 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D08679 Vincristine 4件: 26, 34, 65, 331
47 CACNA1I 7件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, Circadian entrainment 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
48 CACNA1H 7件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, Circadian entrainment 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
49 CACNA1G 8件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, Circadian entrainment 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Cushing syndrome 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
50 MS4A1 1件: Hematopoietic cell lineage 💬 D02994 Rituximab 1件: 331